U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dpyd dihydropyrimidine dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 99586, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dpydprovided by MGI
    Official Full Name
    dihydropyrimidine dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:2139667
    See related
    Ensembl:ENSMUSG00000033308 AllianceGenome:MGI:2139667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DPD; DHPDHase; E330028L06Rik
    Summary
    Enables dihydropyrimidine dehydrogenase (NADP+) activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Acts upstream of or within pyrimidine nucleobase catabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculature; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 19.3), large intestine adult (RPKM 5.5) and 7 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dpyd in Genome Data Viewer
    Location:
    3 G1; 3 51.96 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (118355758..119226573)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (118562109..119432924)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08815 Neighboring gene predicted gene, 26871 Neighboring gene microRNA 137 Neighboring gene predicted gene 9916 Neighboring gene STARR-seq mESC enhancer starr_08816 Neighboring gene STARR-seq mESC enhancer starr_08817 Neighboring gene STARR-seq mESC enhancer starr_08818 Neighboring gene STARR-seq mESC enhancer starr_08819 Neighboring gene STARR-seq mESC enhancer starr_08820 Neighboring gene STARR-seq mESC enhancer starr_08821 Neighboring gene STARR-seq mESC enhancer starr_08822 Neighboring gene predicted gene, 32577 Neighboring gene predicted gene, 32632

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice. Keenan BT, et al. Curr Biol, 2021 Dec 6. PMID 34653361, Free PMC Article
    2. Regulation of dihydropyrimidine dehydrogenase gene expression in regenerating mouse liver. Yamada H, et al. Int J Oncol, 2003 Feb. PMID 12527935
    3. Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression. Porsin B, et al. Eur J Cancer, 2003 Apr. PMID 12651209
    4. cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria. Yokota H, et al. J Biol Chem, 1994 Sep 16. PMID 8083224
    5. Studies of a mutation affecting pyrimidine degradation in inbred mice. Sanno Y, et al. J Biol Chem, 1970 Nov 10. PMID 5472365

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC37940

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydropyrimidine dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uracil binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dCMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dTMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in dUMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleobase catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pyrimidine nucleobase catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to nutrient ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thymidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thymine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thymine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in uracil catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uracil catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in uracil metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dihydropyrimidine dehydrogenase [NADP(+)]
    Names
    dihydrothymine dehydrogenase
    dihydrouracil dehydrogenase
    NP_740748.1
    XP_011238620.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170778.3 → NP_740748.1  dihydropyrimidine dehydrogenase [NADP(+)]

      See identical proteins and their annotated locations for NP_740748.1

      Status: VALIDATED

      Source sequence(s)
      AC110513, AC115012, AC115017, AC115935, AC116409, AC121544, AC122183, AC152401, AC161223
      Consensus CDS
      CCDS17797.1
      UniProtKB/Swiss-Prot
      Q8CHR6
      UniProtKB/TrEMBL
      Q80XT4
      Related
      ENSMUSP00000039429.8, ENSMUST00000039177.12
      Conserved Domains (6) summary
      PRK08318
      Location:532 → 1012
      PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated
      PRK11749
      Location:53 → 511
      PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
      cd02940
      Location:532 → 834
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam13187
      Location:953 → 997
      Fer4_9; 4Fe-4S dicluster domain
      pfam13450
      Location:194 → 238
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam14691
      Location:58 → 168
      Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      118355758..119226573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240318.2 → XP_011238620.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

      Conserved Domains (2) summary
      PRK11749
      Location:53 → 511
      PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
      cl21457
      Location:532 → 580
      TIM; TIM-like beta/alpha barrel domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHR6.1 GenPept UniProtKB/Swiss-Prot:Q8CHR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous