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    Cep70 centrosomal protein 70 [ Mus musculus (house mouse) ]

    Gene ID: 68121, updated on 1-Apr-2024

    Summary

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    Official Symbol
    Cep70provided by MGI
    Official Full Name
    centrosomal protein 70provided by MGI
    Primary source
    MGI:MGI:1915371
    See related
    Ensembl:ENSMUSG00000056267 AllianceGenome:MGI:1915371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bite; 6720484E09Rik; C030018L16Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly and regulation of microtubule cytoskeleton organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome. Orthologous to human CEP70 (centrosomal protein 70). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 3.5), CNS E14 (RPKM 3.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 E3.3; 9 51.45 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99065640..99205569)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99183584..99325879)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene predicted gene, 33857 Neighboring gene STARR-positive B cell enhancer ABC_E9773 Neighboring gene predicted gene 2950 Neighboring gene STARR-seq mESC enhancer starr_25018 Neighboring gene Fas apoptotic inhibitory molecule like Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene Neighboring gene RIKEN cDNA 4930422M22 gene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 14 pseudogene Neighboring gene extended synaptotagmin-like protein 3 Neighboring gene STARR-seq mESC enhancer starr_25024 Neighboring gene muscle and microspikes RAS Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene NME/NM23 family member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cep70 contributes to angiogenesis by modulating microtubule rearrangement and stimulating cell polarization and migration. Shi X, et al. Cell Cycle, 2012 Apr 15. PMID 22437770
    2. Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis. Liu Q, et al. Cell Death Dis, 2021 May 12. PMID 33980814, Free PMC Article
    3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cep70 is important for Cdc42 and Rac1 activation to promote angiogenesis.
      Title: Cep70 contributes to angiogenesis by modulating microtubule rearrangement and stimulating cell polarization and migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 70 kDa
    Names
    p10-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428870.1 → NP_001415799.1  centrosomal protein of 70 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159899

    2. NM_023873.5 → NP_076362.2  centrosomal protein of 70 kDa isoform 1

      See identical proteins and their annotated locations for NP_076362.2

      Status: VALIDATED

      Source sequence(s)
      AC159899
      Consensus CDS
      CCDS40738.1
      UniProtKB/Swiss-Prot
      Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
      Related
      ENSMUSP00000091312.4, ENSMUST00000093795.10
      Conserved Domains (1) summary
      TIGR02169
      Location:98 → 351
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      99065640..99205569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313546.3 → XP_017169035.1  centrosomal protein of 70 kDa isoform X3

    2. XM_030244539.2 → XP_030100399.1  centrosomal protein of 70 kDa isoform X3

    3. XM_030244541.2 → XP_030100401.1  centrosomal protein of 70 kDa isoform X4

    4. XM_036155222.1 → XP_036011115.1  centrosomal protein of 70 kDa isoform X4

    5. XM_036155221.1 → XP_036011114.1  centrosomal protein of 70 kDa isoform X4

    6. XM_030244540.2 → XP_030100400.1  centrosomal protein of 70 kDa isoform X4

    7. XM_030244537.2 → XP_030100397.1  centrosomal protein of 70 kDa isoform X2

      Conserved Domains (1) summary
      TIGR02169
      Location:57 → 310
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    8. XM_030244536.2 → XP_030100396.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
      Conserved Domains (1) summary
      TIGR02169
      Location:98 → 351
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    9. XM_030244534.2 → XP_030100394.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
      Conserved Domains (1) summary
      TIGR02169
      Location:98 → 351
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    10. XM_030244535.2 → XP_030100395.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
      Conserved Domains (1) summary
      TIGR02169
      Location:98 → 351
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    11. XM_030244533.2 → XP_030100393.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
      Conserved Domains (1) summary
      TIGR02169
      Location:98 → 351
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    12. XM_030244538.2 → XP_030100398.1  centrosomal protein of 70 kDa isoform X2

      Conserved Domains (1) summary
      TIGR02169
      Location:57 → 310
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    13. XM_006511393.2 → XP_006511456.1  centrosomal protein of 70 kDa isoform X4

    14. XM_006511391.4 → XP_006511454.1  centrosomal protein of 70 kDa isoform X3

      See identical proteins and their annotated locations for XP_006511454.1

    RNA

    1. XR_003947992.2 RNA Sequence

    2. XR_003947993.2 RNA Sequence

    3. XR_003947990.2 RNA Sequence

    4. XR_003947989.2 RNA Sequence

    5. XR_003947988.2 RNA Sequence

    6. XR_004935539.1 RNA Sequence

    7. XR_001779002.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IQY5.1 GenPept UniProtKB/Swiss-Prot:Q6IQY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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