Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ugt1a2provided by MGI
Official Full Name: UDP glucuronosyltransferase 1 family, polypeptide A2provided by MGI
Primary source: MGI:MGI:3576049
See related: Ensembl:ENSMUSG00000090171 AllianceGenome:MGI:3576049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ugt1; UDPGT 1-2
Summary: Predicted to enable several functions, including glucuronosyltransferase activity; protein dimerization activity; and retinoic acid binding activity. Predicted to be involved in flavonoid glucuronidation and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum. Orthologous to human UGT1A3 (UDP glucuronosyltransferase family 1 member A3) and UGT1A5 (UDP glucuronosyltransferase family 1 member A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 345.2), liver adult (RPKM 147.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 44.54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (88128333..88147724)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (88200611..88220002)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in addition to the extensively studied tapasin-mediated quality control mechanism, UGT1 adds a new level of control in the MHC class I antigen presentation pathway.
Title: A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules.
induced in transgenic mice, functions to eliminate steroids, heme metabolites and environmental toxins
Title: Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 1-2

Names: UDP-glucuronosyltransferase 1 family, member 2; UDP-glucuronosyltransferase 1A2; UDPGT; UGT1*0; UGT1-02; UGT1.2; bilirubin specific; bilirubin-specific UDPGT

NP_038729.1

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013701.3 → NP_038729.1 UDP-glucuronosyltransferase 1-2 precursor

See identical proteins and their annotated locations for NP_038729.1

Status: VALIDATED

Source sequence(s)

AC087780, AK002629

Consensus CDS

CCDS15141.1

UniProtKB/Swiss-Prot

P70691, Q545X2, Q6XL49

Related

ENSMUSP00000037258.9, ENSMUST00000049289.9

Conserved Domains (3) summary

PHA03392
Location:261 → 505

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:28 → 524

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

cl10013
Location:43 → 175

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...