Cadps2 Ca2+-dependent activator protein for secretion 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cadps2provided by MGI
Official Full Name: Ca2+-dependent activator protein for secretion 2provided by MGI
Primary source: MGI:MGI:2443963
See related: Ensembl:ENSMUSG00000017978 AllianceGenome:MGI:2443963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cpd2; Caps2; Caps-2; A230044C21Rik
Summary: Predicted to enable lipid binding activity and metal ion binding activity. Involved in synaptic vesicle priming. Acts upstream of or within cellular response to starvation; hematopoietic stem cell homeostasis; and positive regulation of exocytosis. Located in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Is expressed in several structures, including brain; genitourinary system; sensory organ; skeleton; and spinal cord. Used to study autism spectrum disorder. Orthologous to human CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 18.3), cortex adult (RPKM 6.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 10.57 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (23262765..23840662, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (23262773..23841175, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
Title: Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice.
Title: CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice.
The data suggest that CADPS2-mediated secretion of BDNF/NT-3 may be involved in development and maturation of synapses and in the balance between inhibitory and excitatory synapses.
Title: Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3.
Study looked at synaptic microstructures of hippocampal mossy fiber (MF) terminals in Calcium-dependent activator protein for secretion 2 (Cadps2) knockout mice. Findings suggest that CADPS2 plays a critical role in MF synaptic development and functional organization.
Title: Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals.
results suggest that deregulated gene expression caused by loss of Cadps2 may cause developmental deficits and/or pathological symptoms, resulting in autistic-like phenotypes
Title: Analysis of gene expression in Ca(2+)-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways.
CAPS2 plays an important role in subcellular locality (axonal vs. somato-dendritic) of enhanced BDNF and NT-3 release, which is indispensable for proper development of postnatal cerebellum.
Title: Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum.
Data suggest that adequate levels of CAPS2 are critical for normal brain development and normal behavior; allelic changes due to copy number variation may contribute to autistic behavior.
Title: Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene.
Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice
Title: Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.
results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development
Title: The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival.
identification, cloning, and comparative characterization of a second mammalian CAPS isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1
Title: A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW550108 (e-PCR)
- UniSTS:207929

NoName (e-PCR)
- UniSTS:224843

NoName (e-PCR)
- UniSTS:488666

GDB:1317954 (e-PCR)
- UniSTS:12511

Caps2 (e-PCR), detects polymorphism
- UniSTS:516850

Caps2 (e-PCR), detects polymorphism
- UniSTS:516851

Caps2 (e-PCR), detects polymorphism
- UniSTS:516852

Caps2 (e-PCR), detects polymorphism
- UniSTS:516853

MHAa88f8.seq (e-PCR)
- UniSTS:125437

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in dense core granule exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle priming	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptic vesicle priming	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle priming	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
NOT located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium-dependent secretion activator 2

Names: cerebellum postnatal development associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252105.2 → NP_001239034.1 calcium-dependent secretion activator 2 isoform 2

See identical proteins and their annotated locations for NP_001239034.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2, also known as CAPS2a) that is shorter than isoform 1.

Source sequence(s)

AC153636, AC153639, AC153831, AC155850, AC167725

Consensus CDS

CCDS57412.1

UniProtKB/TrEMBL

E9Q835

Related

ENSMUSP00000111015.3, ENSMUST00000115358.9

Conserved Domains (4) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam00169
Location:493 → 592

PH; PH domain

pfam06292
Location:802 → 902

DUF1041; Domain of Unknown Function (DUF1041)
NM_001252106.2 → NP_001239035.1 calcium-dependent secretion activator 2 isoform 3

See identical proteins and their annotated locations for NP_001239035.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, but includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3, also known as CAPS2c) is shorter than isoform 1.

Source sequence(s)

AC153636, AC153639, AC153831, AC155850, AC167725

UniProtKB/TrEMBL

A4PI82, E9Q835

Conserved Domains (4) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 611

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam00169
Location:493 → 558

PH; PH domain

pfam06292
Location:735 → 835

DUF1041; Domain of Unknown Function (DUF1041)
NM_001252107.2 → NP_001239036.1 calcium-dependent secretion activator 2 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several exons in the central and 3' coding regions, but includes an alternate 3' exon and thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4, also known as CAPS2d) has a distinct and significantly shorter C-terminus, compared to isoform 1.

Source sequence(s)

AC153636, AC153831, AC155850, AC167725

Consensus CDS

CCDS57413.1

UniProtKB/TrEMBL

A4PI83

Related

ENSMUSP00000111013.3, ENSMUST00000115356.3

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam00169
Location:493 → 592

PH; PH domain
NM_001252108.2 → NP_001239037.1 calcium-dependent secretion activator 2 isoform 5

See identical proteins and their annotated locations for NP_001239037.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks several exons in the central and 3' coding regions, but includes an alternate 3' exon and thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5, also known as CAPS2e) has a distinct and significantly shorter C-terminus, compared to isoform 1.

Source sequence(s)

AC153636, AC153831, AC155850, AC167725

UniProtKB/TrEMBL

A4PI83, A4PI84

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam00169
Location:493 → 592

PH; PH domain
NM_001252109.1 → NP_001239038.1 calcium-dependent secretion activator 2 isoform 6

See identical proteins and their annotated locations for NP_001239038.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks several exons in the central and 3' coding regions, but includes an alternate 3' exon and thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6, also known as CAPS2f) has a distinct and significantly shorter C-terminus, compared to isoform 1.

Source sequence(s)

AB291946, AC153636

UniProtKB/TrEMBL

A4PI80
NM_001252110.2 → NP_001239039.1 calcium-dependent secretion activator 2 isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks three in-frame exons in the central coding region, but includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.

Source sequence(s)

AC153636, AC153639, AC153831, AC155850, AC167725

Consensus CDS

CCDS57411.1

UniProtKB/TrEMBL

A0A0M3HEP6

Related

ENSMUSP00000111018.3, ENSMUST00000115361.9

Conserved Domains (4) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam00169
Location:493 → 592

PH; PH domain

pfam06292
Location:802 → 892

DUF1041; Domain of Unknown Function (DUF1041)
NM_001403608.1 → NP_001390537.1 calcium-dependent secretion activator 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC153636, AC153639, AC153831, AC155850, AC167725
NM_001403630.1 → NP_001390559.1 calcium-dependent secretion activator 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC153636, AC153639, AC153831, AC155850, AC167725

UniProtKB/Swiss-Prot

O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8BYR5, Q8K3K6

Related

ENSMUSP00000064876.9, ENSMUST00000069074.14
NM_153163.5 → NP_694803.3 calcium-dependent secretion activator 2 isoform 1

See identical proteins and their annotated locations for NP_694803.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CAPS2b).

Source sequence(s)

AC153636, AC153639, AC153831, AC155850, AC167725

Consensus CDS

CCDS39439.1

UniProtKB/TrEMBL

A4PI81, E9Q835

Related

ENSMUSP00000018122.8, ENSMUST00000018122.14

Conserved Domains (4) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam00169
Location:493 → 592

PH; PH domain

pfam06292
Location:802 → 902

DUF1041; Domain of Unknown Function (DUF1041)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

23262765..23840662 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166226.1 → XP_036022119.1 calcium-dependent secretion activator 2 isoform X7

UniProtKB/TrEMBL

A0A0M3HEP6

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 892

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505111.3 → XP_006505174.1 calcium-dependent secretion activator 2 isoform X5

UniProtKB/TrEMBL

A0A0M3HEP6

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 890

DUF1041; Domain of Unknown Function (DUF1041)
XM_030255457.2 → XP_030111317.1 calcium-dependent secretion activator 2 isoform X13

UniProtKB/TrEMBL

A0A0M3HEP6

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 893

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505109.3 → XP_006505172.1 calcium-dependent secretion activator 2 isoform X3

UniProtKB/TrEMBL

A0A0M3HEP6

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 893

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505115.3 → XP_006505178.1 calcium-dependent secretion activator 2 isoform X12

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 897

DUF1041; Domain of Unknown Function (DUF1041)
XM_036166228.1 → XP_036022121.1 calcium-dependent secretion activator 2 isoform X16

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 899

DUF1041; Domain of Unknown Function (DUF1041)
XM_036166227.1 → XP_036022120.1 calcium-dependent secretion activator 2 isoform X10

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 899

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505110.3 → XP_006505173.1 calcium-dependent secretion activator 2 isoform X4

See identical proteins and their annotated locations for XP_006505173.1

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 897

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505108.3 → XP_006505171.1 calcium-dependent secretion activator 2 isoform X2

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 897

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505113.3 → XP_006505176.1 calcium-dependent secretion activator 2 isoform X8

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 900

DUF1041; Domain of Unknown Function (DUF1041)
XM_017321641.3 → XP_017177130.1 calcium-dependent secretion activator 2 isoform X15

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 900

DUF1041; Domain of Unknown Function (DUF1041)
XM_017321640.3 → XP_017177129.1 calcium-dependent secretion activator 2 isoform X11

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 900

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505107.3 → XP_006505170.1 calcium-dependent secretion activator 2 isoform X1

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 900

DUF1041; Domain of Unknown Function (DUF1041)
XM_006505114.4 → XP_006505177.1 calcium-dependent secretion activator 2 isoform X9

UniProtKB/TrEMBL

E9Q835

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 900

DUF1041; Domain of Unknown Function (DUF1041)