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    Mterf3 mitochondrial transcription termination factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 66410, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mterf3provided by MGI
    Official Full Name
    mitochondrial transcription termination factor 3provided by MGI
    Primary source
    MGI:MGI:1913660
    See related
    Ensembl:ENSMUSG00000021519 AllianceGenome:MGI:1913660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mterfd1; 2410017I18Rik
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in mitochondrion. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human MTERF3 (mitochondrial transcription termination factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.6), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 B3; 13 34.54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67053520..67081148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (66906577..66933083, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34888 Neighboring gene high mobility group box 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67006259-67006368 Neighboring gene ubiquinol-cytochrome c reductase binding protein Neighboring gene RNA guanine-7 methyltransferase activating subunit like Neighboring gene STARR-positive B cell enhancer ABC_E10799 Neighboring gene STARR-seq mESC enhancer starr_34889 Neighboring gene phosphatidylserine synthase 1 Neighboring gene RIKEN cDNA 4933433G19 gene Neighboring gene STARR-seq mESC enhancer starr_34892 Neighboring gene zinc finger protein 712 Neighboring gene STARR-positive B cell enhancer ABC_E3085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced cardiomyocyte Ca(2+) cycling precedes terminal AV-block in mitochondrial cardiomyopathy Mterf3 KO mice. Andersson DC, et al. Antioxid Redox Signal, 2011 Nov 1. PMID 21381862
    2. Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation. Dorado B, et al. Hum Mol Genet, 2011 Jan 1. PMID 20940150, Free PMC Article
    3. MTERF3 is a negative regulator of mammalian mtDNA transcription. Park CB, et al. Cell, 2007 Jul 27. PMID 17662942
    4. MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. Wredenberg A, et al. PLoS Genet, 2013. PMID 23300484, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription termination factor 3, mitochondrial
    Names
    MTERF domain containing 1
    mTERF domain-containing protein 1, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025547.4 → NP_079823.2  transcription termination factor 3, mitochondrial precursor

      See identical proteins and their annotated locations for NP_079823.2

      Status: VALIDATED

      Source sequence(s)
      AC124433
      Consensus CDS
      CCDS26611.1
      UniProtKB/Swiss-Prot
      Q8R3J4, Q9CSV1, Q9CWM7
      Related
      ENSMUSP00000021991.5, ENSMUST00000021991.11
      Conserved Domains (1) summary
      cl19765
      Location:148 → 350
      mTERF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67053520..67081148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517322.4 → XP_006517385.1  transcription termination factor 3, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl19765
      Location:148 → 348
      mTERF

    2. XM_036158110.1 → XP_036014003.1  transcription termination factor 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl19765
      Location:148 → 363
      mTERF

    3. XM_011244548.4 → XP_011242850.1  transcription termination factor 3, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011242850.1

      UniProtKB/Swiss-Prot
      Q8R3J4, Q9CSV1, Q9CWM7
      Conserved Domains (1) summary
      cl19765
      Location:148 → 350
      mTERF

    4. XM_017315563.3 → XP_017171052.1  transcription termination factor 3, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8R3J4, Q9CSV1, Q9CWM7
      Conserved Domains (1) summary
      cl19765
      Location:148 → 350
      mTERF

    5. XM_006517321.3 → XP_006517384.1  transcription termination factor 3, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006517384.1

      UniProtKB/Swiss-Prot
      Q8R3J4, Q9CSV1, Q9CWM7
      Conserved Domains (1) summary
      cl19765
      Location:148 → 350
      mTERF

    6. XM_036158114.1 → XP_036014007.1  transcription termination factor 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl19765
      Location:148 → 363
      mTERF

    7. XM_036158111.1 → XP_036014004.1  transcription termination factor 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl19765
      Location:148 → 363
      mTERF

    8. XM_030247357.2 → XP_030103217.1  transcription termination factor 3, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8R3J4, Q9CSV1, Q9CWM7
      Conserved Domains (1) summary
      cl19765
      Location:148 → 350
      mTERF

    9. XM_036158113.1 → XP_036014006.1  transcription termination factor 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl19765
      Location:148 → 363
      mTERF

    10. XM_036158112.1 → XP_036014005.1  transcription termination factor 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl19765
      Location:148 → 363
      mTERF

    RNA

    1. XR_004938051.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3J4.1 GenPept UniProtKB/Swiss-Prot:Q8R3J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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