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    Zfhx4 zinc finger homeodomain 4 [ Mus musculus (house mouse) ]

    Gene ID: 80892, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfhx4provided by MGI
    Official Full Name
    zinc finger homeodomain 4provided by MGI
    Primary source
    MGI:MGI:2137668
    See related
    Ensembl:ENSMUSG00000025255 AllianceGenome:MGI:2137668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfh4; Zfh-4; A930021B15; C130041O22Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; retina; and skin. Orthologous to human ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 10.6), CNS E11.5 (RPKM 7.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 A1; 3 1.96 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (5276268..5480921)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (5218218..5415861)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06803 Neighboring gene predicted gene, 52665 Neighboring gene STARR-seq mESC enhancer starr_06804 Neighboring gene predicted gene, 17308 Neighboring gene RIKEN cDNA 2700069I18 gene Neighboring gene VISTA enhancer mm1577 Neighboring gene VISTA enhancer mm1541 Neighboring gene RIKEN cDNA 4930555M17 gene Neighboring gene peroxisomal biogenesis factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A homeodomain-zinc finger protein, ZFHX4, is expressed in neuronal differentiation manner and suppressed in muscle differentiation manner. Hemmi K, et al. Biol Pharm Bull, 2006 Sep. PMID 16946494
    2. Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle. Kostich WA, et al. Dev Dyn, 1995 Feb. PMID 7537552
    3. The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers. Sakata N, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873665
    4. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Chudnovsky Y, et al. Cell Rep, 2014 Jan 30. PMID 24440720, Free PMC Article
    5. Behavioral abnormalities observed in Zfhx2-deficient mice. Komine Y, et al. PLoS One, 2012. PMID 23300874, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.
      Title: Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.
    2. Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.
      Title: Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger homeobox protein 4
    Names
    zinc finger homeodomain protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368671.1 → NP_001355600.1  zinc finger homeobox protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115031, AC118246
      UniProtKB/TrEMBL
      H3BLK8
      Conserved Domains (6) summary
      smart00389
      Location:2127 → 2182
      HOX; Homeodomain
      COG5189
      Location:1468 → 1608
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5576
      Location:2536 → 2658
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:1540 → 1564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1396 → 1416
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2226 → 2280
      Homeobox; Homeobox domain

    2. NM_030708.2 → NP_109633.2  zinc finger homeobox protein 4 isoform 2

      See identical proteins and their annotated locations for NP_109633.2

      Status: VALIDATED

      Source sequence(s)
      AC115031, AC118246, BC061199, BI988177
      Consensus CDS
      CCDS38382.1
      UniProtKB/TrEMBL
      E9Q5A7, H3BLK8
      Related
      ENSMUSP00000026284.7, ENSMUST00000026284.13
      Conserved Domains (6) summary
      smart00389
      Location:2101 → 2156
      HOX; Homeodomain
      COG5189
      Location:1442 → 1582
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5576
      Location:2510 → 2632
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:1514 → 1538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1370 → 1390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2200 → 2254
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      5276268..5480921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163423.1 → XP_036019316.1  zinc finger homeobox protein 4 isoform X1

      UniProtKB/TrEMBL
      H3BLK8
      Conserved Domains (6) summary
      smart00389
      Location:2127 → 2182
      HOX; Homeodomain
      COG5189
      Location:1468 → 1608
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5576
      Location:2536 → 2658
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:1540 → 1564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1396 → 1416
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2226 → 2280
      Homeobox; Homeobox domain

    2. XM_006530105.5 → XP_006530168.1  zinc finger homeobox protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006530168.1

      UniProtKB/TrEMBL
      H3BLK8
      Related
      ENSMUSP00000135827.2, ENSMUST00000175866.8
      Conserved Domains (6) summary
      smart00389
      Location:2127 → 2182
      HOX; Homeodomain
      COG5189
      Location:1468 → 1608
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5576
      Location:2536 → 2658
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:1540 → 1564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1396 → 1416
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2226 → 2280
      Homeobox; Homeobox domain

    3. XM_006530106.4 → XP_006530169.1  zinc finger homeobox protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006530169.1

      UniProtKB/TrEMBL
      E9Q5A7, H3BLK8
      Conserved Domains (6) summary
      smart00389
      Location:2101 → 2156
      HOX; Homeodomain
      COG5189
      Location:1442 → 1582
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5576
      Location:2510 → 2632
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:1514 → 1538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1370 → 1390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2200 → 2254
      Homeobox; Homeobox domain

    4. XM_017319816.3 → XP_017175305.1  zinc finger homeobox protein 4 isoform X1

      UniProtKB/TrEMBL
      H3BLK8
      Conserved Domains (6) summary
      smart00389
      Location:2127 → 2182
      HOX; Homeodomain
      COG5189
      Location:1468 → 1608
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5576
      Location:2536 → 2658
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:1540 → 1564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1396 → 1416
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2226 → 2280
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJN2.1 GenPept UniProtKB/Swiss-Prot:Q9JJN2

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