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    4931406C07Rik RIKEN cDNA 4931406C07 gene [ Mus musculus (house mouse) ]

    Gene ID: 70984, updated on 5-Mar-2024

    Summary

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    Official Symbol
    4931406C07Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 4931406C07 geneprovided by MGI
    Primary source
    MGI:MGI:1918234
    See related
    Ensembl:ENSMUSG00000031938 AllianceGenome:MGI:1918234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; neural retina; and nucleus pulposus. Orthologous to human C11orf54 (chromosome 11 open reading frame 54). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 50.7), subcutaneous fat pad adult (RPKM 17.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A2; 9 4.76 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15194633..15217836, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15283337..15306448, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51702 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene mediator complex subunit 17 Neighboring gene STARR-seq mESC enhancer starr_23372 Neighboring gene STARR-positive B cell enhancer ABC_E6715 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D Neighboring gene microRNA 7650 Neighboring gene predicted gene, 24455

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation. Chu R, et al. Mol Cell Biol, 2004 Jul. PMID 15226431, Free PMC Article
    2. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    3. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    4. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on ester bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ester hydrolase C11orf54 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199484.1 → NP_001186413.1  ester hydrolase C11orf54 homolog isoform 1

      See identical proteins and their annotated locations for NP_001186413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC154296, AK133192, CK384052
      Consensus CDS
      CCDS22835.1
      UniProtKB/Swiss-Prot
      Q91V76
      Related
      ENSMUSP00000136717.2, ENSMUST00000180339.8
      Conserved Domains (1) summary
      cd17298
      Location:14 → 304
      DUF1907; proteins similar to putative ester hydrolase C11orf54/PTD012

    2. NM_001199485.1 → NP_001186414.1  ester hydrolase C11orf54 homolog isoform 1

      See identical proteins and their annotated locations for NP_001186414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' UTR segment, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK016432, AK147073, BY118027, CK384052
      Consensus CDS
      CCDS22835.1
      UniProtKB/Swiss-Prot
      Q91V76
      Related
      ENSMUSP00000136335.2, ENSMUST00000178977.9
      Conserved Domains (1) summary
      cd17298
      Location:14 → 304
      DUF1907; proteins similar to putative ester hydrolase C11orf54/PTD012

    3. NM_001359258.1 → NP_001346187.1  ester hydrolase C11orf54 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC154296
      Consensus CDS
      CCDS90500.1
      UniProtKB/TrEMBL
      A0A1L1SSF8
      Related
      ENSMUSP00000149878.2, ENSMUST00000216955.2
      Conserved Domains (1) summary
      cd17298
      Location:8 → 271
      DUF1907; proteins similar to putative ester hydrolase C11orf54/PTD012

    4. NM_133732.3 → NP_598493.1  ester hydrolase C11orf54 homolog isoform 1

      See identical proteins and their annotated locations for NP_598493.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' UTR segment, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC154296, AK133192, CK384052, CT010296
      Consensus CDS
      CCDS22835.1
      UniProtKB/Swiss-Prot
      Q91V76
      Related
      ENSMUSP00000034414.9, ENSMUST00000034414.10
      Conserved Domains (1) summary
      cd17298
      Location:14 → 304
      DUF1907; proteins similar to putative ester hydrolase C11orf54/PTD012

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15194633..15217836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155283.1 → XP_036011176.1  ester hydrolase C11orf54 homolog isoform X2

      UniProtKB/TrEMBL
      A0A1L1SSF8
      Conserved Domains (1) summary
      cd17298
      Location:8 → 271
      DUF1907; proteins similar to putative ester hydrolase C11orf54/PTD012

    2. XM_030244585.2 → XP_030100445.1  ester hydrolase C11orf54 homolog isoform X3

      Conserved Domains (1) summary
      pfam08925
      Location:1 → 192
      DUF1907; Domain of Unknown Function (DUF1907)

    3. XM_006510596.3 → XP_006510659.1  ester hydrolase C11orf54 homolog isoform X1

      See identical proteins and their annotated locations for XP_006510659.1

      UniProtKB/Swiss-Prot
      Q91V76
      Conserved Domains (1) summary
      cd17298
      Location:14 → 304
      DUF1907; proteins similar to putative ester hydrolase C11orf54/PTD012
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91V76.1 GenPept UniProtKB/Swiss-Prot:Q91V76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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