Dok5 docking protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dok5provided by MGI
Official Full Name: docking protein 5provided by MGI
Primary source: MGI:MGI:1924079
See related: Ensembl:ENSMUSG00000027560 AllianceGenome:MGI:1924079
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700055C10Rik
Summary: Acts upstream of or within neuron differentiation; positive regulation of MAPK cascade; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DOK5 (docking protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 19.0), CNS E14 (RPKM 9.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 92.26 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (170573722..170721695)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (170731807..170879775)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/beta-catenin signaling.
Title: Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/β-catenin signaling.
The study suggests that miR-141-3p inhibits retinal neovascularization in glaucoma mice by impeding the activation of the DOK5-mediated MAPK signaling pathway.
Title: MicroRNA-141-3p inhibits retinal neovascularization and retinal ganglion cell apoptosis in glaucoma mice through the inactivation of Docking protein 5-dependent mitogen-activated protein kinase signaling pathway.
IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
Title: The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.
Dok5 is necessary for NT-3 signaling to block TrkC-induced apoptosis
Title: Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.
FOXO3a, the PI3K/PKB downstream substrate, acts as a transcriptional repressor to inhibit the expression of Dok-5.
Title: Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit344 (e-PCR), detects polymorphism
- UniSTS:129238

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: docking protein 5

Names: downstream of tyrosine kinase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163686.1 → NP_001157158.1 docking protein 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK044148, BY248468, BY657780, CJ064232

UniProtKB/TrEMBL

Q6NXY7

Conserved Domains (3) summary

cd13164
Location:133 → 235

PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)

cd14678
Location:9 → 113

PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

pfam00169
Location:8 → 111

PH; PH domain
NM_029761.4 → NP_084037.3 docking protein 5 isoform 1

See identical proteins and their annotated locations for NP_084037.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK044148, BY248468, BY657780, CJ064232

Consensus CDS

CCDS17125.1

UniProtKB/Swiss-Prot

Q8BRI3, Q91ZM9, Q9CSM6

UniProtKB/TrEMBL

Q6NXY7

Related

ENSMUSP00000029075.5, ENSMUST00000029075.5

Conserved Domains (3) summary

cd13164
Location:133 → 235

PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)

cd14678
Location:9 → 113

PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

pfam00169
Location:8 → 111

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

170573722..170721695

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162678.1 → XP_036018571.1 docking protein 5 isoform X1

Conserved Domains (1) summary

cl17171
Location:53 → 129

PH-like; Pleckstrin homology-like domain