Coa6 cytochrome c oxidase assembly factor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coa6provided by MGI
Official Full Name: cytochrome c oxidase assembly factor 6provided by MGI
Primary source: MGI:MGI:1915142
See related: Ensembl:ENSMUSG00000051671 AllianceGenome:MGI:1915142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810063B05Rik
Summary: Predicted to enable copper ion binding activity. Predicted to be involved in mitochondrial ATP synthesis coupled electron transport; plasma membrane ATP synthesis coupled electron transport; and respiratory chain complex IV assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 4. Orthologous to human COA6 (cytochrome c oxidase assembly factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 35.5), adrenal adult (RPKM 29.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 74.08 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (127149267..127152174)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (126422501..126425435)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
involved_in respiratory chain complex IV assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in respiratory chain complex IV assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c oxidase assembly factor 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174987.5 → NP_778152.1 cytochrome c oxidase assembly factor 6 homolog

See identical proteins and their annotated locations for NP_778152.1

Status: VALIDATED

Source sequence(s)

AC151908

Consensus CDS

CCDS52709.1

UniProtKB/Swiss-Prot

Q8BGD8

Related

ENSMUSP00000058279.5, ENSMUST00000059093.7

Conserved Domains (1) summary

cd00926
Location:4 → 64

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...