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    Stk32c serine/threonine kinase 32C [ Mus musculus (house mouse) ]

    Gene ID: 57740, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Stk32cprovided by MGI
    Official Full Name
    serine/threonine kinase 32Cprovided by MGI
    Primary source
    MGI:MGI:2385336
    See related
    Ensembl:ENSMUSG00000015981 AllianceGenome:MGI:2385336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKE; Pkek; YANK3
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Is expressed in brain; gonad; large intestine; metanephros; and skin. Orthologous to human STK32C (serine/threonine kinase 32C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 32.1), frontal lobe adult (RPKM 29.4) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F4; 7 84.03 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138683554..138793223, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139103638..139213307, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20414 Neighboring gene janus kinase and microtubule interacting protein 3 Neighboring gene dihydropyrimidinase-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E11373 Neighboring gene STARR-positive B cell enhancer ABC_E296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:146410713-146410866 Neighboring gene leucine rich repeat containing 27 Neighboring gene predicted gene, 32315 Neighboring gene PWWP domain containing 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 32C
    Names
    PKE protein kinase
    NP_001156012.1
    NP_001407042.1
    NP_001407043.1
    NP_067277.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162540.1 → NP_001156012.1  serine/threonine-protein kinase 32C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB041542, AC093363, AC174642, AK046439
      Consensus CDS
      CCDS52425.1
      UniProtKB/TrEMBL
      E9PXK4
      Related
      ENSMUSP00000126638.2, ENSMUST00000165870.2
      Conserved Domains (2) summary
      COG0515
      Location:2 → 336
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05578
      Location:1 → 234
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    2. NM_001420113.1 → NP_001407042.1  serine/threonine-protein kinase 32C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC174642

    3. NM_001420114.1 → NP_001407043.1  serine/threonine-protein kinase 32C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC174642

    4. NM_021302.4 → NP_067277.2  serine/threonine-protein kinase 32C isoform 1

      See identical proteins and their annotated locations for NP_067277.2

      Status: VALIDATED

      Source sequence(s)
      AC174642
      Consensus CDS
      CCDS21952.1
      UniProtKB/Swiss-Prot
      Q8QZV4, Q9JJG4
      Related
      ENSMUSP00000016125.6, ENSMUST00000016125.12
      Conserved Domains (2) summary
      smart00220
      Location:94 → 349
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:93 → 352
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      138683554..138793223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZV4.1 GenPept UniProtKB/Swiss-Prot:Q8QZV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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