Bahd1 bromo adjacent homology domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bahd1provided by MGI
Official Full Name: bromo adjacent homology domain containing 1provided by MGI
Primary source: MGI:MGI:2139371
See related: Ensembl:ENSMUSG00000040007 AllianceGenome:MGI:2139371
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm117; mKIAA0945
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in heterochromatin assembly and negative regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleoplasm. Predicted to be part of chromatin silencing complex. Orthologous to human BAHD1 (bromo adjacent homology domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 26.1), ovary adult (RPKM 14.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (118730817..118755009)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (118900336..118924528)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases
Title: Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
computational approaches leveraging public gene expression data can be used to infer potential genes or proteins for diseases, and BAHD1 might act as an indispensable factor in regulating the cellular inflammatory response in UC.
Title: Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis.
findings show a Listeria virulence factor, lmo0438/lntA, could target the chromatin repressor BAHD1 in host cell nucleus to activate interferon-stimulated genes; LntA-BAHD1 interplay may modulate IFN-lambda-mediated immune response to control host colonization
Title: A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125394 (e-PCR)
- UniSTS:162216

AW541238 (e-PCR)
- UniSTS:178681

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin silencing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin silencing complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bromo adjacent homology domain-containing 1 protein

Names: BAH domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045523.2 → NP_001038988.1 bromo adjacent homology domain-containing 1 protein

Status: VALIDATED

Source sequence(s)

AL772255, AL845164

Consensus CDS

CCDS38202.1

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

UniProtKB/TrEMBL

Z4YJL0

Related

ENSMUSP00000043130.7, ENSMUST00000036578.7

Conserved Domains (3) summary

PHA03247
Location:149 → 369

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:279 → 563

PHA03307; transcriptional regulator ICP4; Provisional

cd04714
Location:615 → 725

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

118730817..118755009

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499265.4 → XP_006499328.1 bromo adjacent homology domain-containing 1 protein isoform X1

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

Conserved Domains (3) summary

PHA03247
Location:158 → 378

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:288 → 572

PHA03307; transcriptional regulator ICP4; Provisional

cd04714
Location:624 → 734

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
XM_006499267.4 → XP_006499330.1 bromo adjacent homology domain-containing 1 protein isoform X3

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

Conserved Domains (3) summary

PHA03247
Location:158 → 378

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:288 → 572

PHA03307; transcriptional regulator ICP4; Provisional

cd04714
Location:624 → 731

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
XM_006499266.5 → XP_006499329.1 bromo adjacent homology domain-containing 1 protein isoform X2

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

Conserved Domains (2) summary

PHA03247
Location:206 → 568

PHA03247; large tegument protein UL36; Provisional

cd04714
Location:623 → 733

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
XM_030250366.2 → XP_030106226.1 bromo adjacent homology domain-containing 1 protein isoform X5

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

Conserved Domains (3) summary

PHA03247
Location:149 → 369

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:279 → 563

PHA03307; transcriptional regulator ICP4; Provisional

cd04714
Location:615 → 722

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
XM_036161341.1 → XP_036017234.1 bromo adjacent homology domain-containing 1 protein isoform X6

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

Conserved Domains (2) summary

PHA03247
Location:197 → 559

PHA03247; large tegument protein UL36; Provisional

cd04714
Location:614 → 721

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
XM_030250363.1 → XP_030106223.1 bromo adjacent homology domain-containing 1 protein isoform X4

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

UniProtKB/TrEMBL

Z4YJL0

Conserved Domains (3) summary

PHA03247
Location:149 → 369

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:279 → 563

PHA03307; transcriptional regulator ICP4; Provisional

cd04714
Location:615 → 725

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
XM_030250365.1 → XP_030106225.1 bromo adjacent homology domain-containing 1 protein isoform X4

UniProtKB/Swiss-Prot

A2AQV1, A6PWW9, B2RUB2, B7ZNH0, Q497V6, Q6ZQ21, Q80VH7

UniProtKB/TrEMBL

Z4YJL0

Conserved Domains (3) summary

PHA03247
Location:149 → 369

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:279 → 563

PHA03307; transcriptional regulator ICP4; Provisional

cd04714
Location:615 → 725

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...