Rnf133 ring finger protein 133 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf133provided by MGI
Official Full Name: ring finger protein 133provided by MGI
Primary source: MGI:MGI:2677436
See related: Ensembl:ENSMUSG00000051956 AllianceGenome:MGI:2677436
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Greul2
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in protein autoubiquitination. Located in endoplasmic reticulum membrane. Is expressed in several structures, including brain; male reproductive gland or organ; submandibular gland; thymus; and trachea. Orthologous to human RNF133 (ring finger protein 133). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 52.9) See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 11.01 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (23648868..23650304, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (23648869..23650305, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.
Title: The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.
Study identified a potential testis-specific gene named Rnf133.
Title: Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF133

Names: RING-type E3 ubiquitin transferase RNF133; goliath-related E3 ubiquitin-protein ligase 2

NP_937894.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198251.2 → NP_937894.1 E3 ubiquitin-protein ligase RNF133

See identical proteins and their annotated locations for NP_937894.1

Status: PROVISIONAL

Source sequence(s)

AK028082

Consensus CDS

CCDS19938.1

UniProtKB/Swiss-Prot

Q14B02, Q8C1F1, Q8CGR0

Related

ENSMUSP00000066906.4, ENSMUST00000063548.4

Conserved Domains (2) summary

cd02122
Location:43 → 159

PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...

pfam13639
Location:211 → 254

zf-RING_2; Ring finger domain