Plppr5 phospholipid phosphatase related 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plppr5provided by MGI
Official Full Name: phospholipid phosphatase related 5provided by MGI
Primary source: MGI:MGI:1923019
See related: Ensembl:ENSMUSG00000033342 AllianceGenome:MGI:1923019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lppr5; PRG-5; Pap2d; 4833424O15Rik
Summary: Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Involved in positive regulation of filopodium assembly and positive regulation of neuron projection development. Located in plasma membrane. Orthologous to human PLPPR5 (phospholipid phosphatase related 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 3.1), CNS E18 (RPKM 1.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 51.21 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (117368274..117483157)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (117574608..117689508)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice.
Title: Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice.
Data indicate that plasticity-related genes 5 (PRG5) expression is involved in proper spine formation.
Title: Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons.
Data show that PRG5 induces filopodia growth independently of Cdc42, and that axon collapse and RhoA activation induced by LPA and myelin-associated neurite inhibitor Nogo-A is attenuated in the presence of PRG5.
Title: Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

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Markers

G67074 (e-PCR)
- UniSTS:178283

D3Mit250 (e-PCR), detects polymorphism
- UniSTS:129675

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipid phosphatase-related protein type 5

Names: lipid phosphate phosphatase-related protein type 5; phosphatidic acid phosphatase type 2d; plasticity-related gene 5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305451.1 → NP_001292380.1 phospholipid phosphatase-related protein type 5 isoform 1

See identical proteins and their annotated locations for NP_001292380.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC116774, AC122030, AK032034, AK076176

Consensus CDS

CCDS80009.1

UniProtKB/Swiss-Prot

Q8BIL7, Q8BJ52, Q8K0B6, Q9D606

UniProtKB/TrEMBL

A0A5F8MPS1

Related

ENSMUSP00000102081.3, ENSMUST00000106473.5

Conserved Domains (1) summary

cd03384
Location:118 → 267

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_029425.3 → NP_083701.2 phospholipid phosphatase-related protein type 5 isoform 2

See identical proteins and their annotated locations for NP_083701.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC122030, AK014763, AK043629, BB351291, BB611685, BB622243, CB722774

Consensus CDS

CCDS17796.1

UniProtKB/TrEMBL

A0A5F8MPS1

Related

ENSMUSP00000045121.7, ENSMUST00000039564.11

Conserved Domains (1) summary

cd03384
Location:118 → 267

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

117368274..117483157

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163380.1 → XP_036019273.1 phospholipid phosphatase-related protein type 5 isoform X3

Conserved Domains (1) summary

cl00474
Location:118 → 207

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
XM_036163381.1 → XP_036019274.1 phospholipid phosphatase-related protein type 5 isoform X4

Conserved Domains (1) summary

cl00474
Location:118 → 208

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
XM_036163382.1 → XP_036019275.1 phospholipid phosphatase-related protein type 5 isoform X5

Conserved Domains (1) summary

cl00474
Location:118 → 207

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
XM_036163379.1 → XP_036019272.1 phospholipid phosphatase-related protein type 5 isoform X2

Conserved Domains (1) summary

cd03384
Location:118 → 266

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
XM_036163378.1 → XP_036019271.1 phospholipid phosphatase-related protein type 5 isoform X1

UniProtKB/TrEMBL

A0A5F8MPS1

Conserved Domains (1) summary

cd03384
Location:118 → 267

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...