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    Khk ketohexokinase [ Mus musculus (house mouse) ]

    Gene ID: 16548, updated on 6-May-2021

    Summary

    Official Symbol
    Khkprovided by MGI
    Official Full Name
    ketohexokinaseprovided by MGI
    Primary source
    MGI:MGI:1096353
    See related
    Ensembl:ENSMUSG00000029162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in kidney adult (RPKM 274.9), liver adult (RPKM 172.1) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Khk in Genome Data Viewer
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31078780..31088592)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30921436..30931248)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31224268..31233619)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 5 Neighboring gene oligosaccharyltransferase complex subunit 4 (non-catalytic) Neighboring gene elastin microfibril interfacer 1 Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ketohexokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ketohexokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ketohexokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IC
    Inferred by Curator
    more info
    PubMed 
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within fructose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fructose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycolytic process through fructose-1-phosphate IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to fructose IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to sucrose IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to sucrose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ketohexokinase
    Names
    hepatic fructokinase
    NP_001297453.1
    NP_001297454.1
    NP_001335995.1
    NP_032465.2
    XP_006503811.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310524.1NP_001297453.1  ketohexokinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC109606
      Consensus CDS
      CCDS80243.1
      UniProtKB/TrEMBL
      E9Q1Q9
      Related
      ENSMUSP00000031053.10, ENSMUST00000031053.15
      Conserved Domains (1) summary
      cd01939
      Location:5340
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    2. NM_001310525.1NP_001297454.1  ketohexokinase isoform 3

      See identical proteins and their annotated locations for NP_001297454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC109606
      UniProtKB/TrEMBL
      A0A0J9YUK6
      Related
      ENSMUSP00000144226.2, ENSMUST00000201571.4
      Conserved Domains (1) summary
      cd01939
      Location:5250
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    3. NM_001349066.1NP_001335995.1  ketohexokinase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC109606
      Related
      ENSMUSP00000143850.2, ENSMUST00000202752.2
      Conserved Domains (1) summary
      cd01939
      Location:5295
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    4. NM_008439.4NP_032465.2  ketohexokinase isoform 2

      See identical proteins and their annotated locations for NP_032465.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC109606
      Consensus CDS
      CCDS39050.1
      UniProtKB/Swiss-Prot
      P97328
      UniProtKB/TrEMBL
      A0A0J9YU79
      Related
      ENSMUSP00000144050.2, ENSMUST00000201621.4
      Conserved Domains (1) summary
      cd01939
      Location:5295
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31078780..31088592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503748.2XP_006503811.1  ketohexokinase isoform X1

      Conserved Domains (1) summary
      cd01939
      Location:5302
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
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