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    Snx15 sorting nexin 15 [ Mus musculus (house mouse) ]

    Gene ID: 69024, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snx15provided by MGI
    Official Full Name
    sorting nexin 15provided by MGI
    Primary source
    MGI:MGI:1916274
    See related
    Ensembl:ENSMUSG00000024787 AllianceGenome:MGI:1916274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500032B08Rik; E130013C21Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in early endosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human SNX15 (sorting nexin 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 16.5), liver E14 (RPKM 14.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6169429..6182446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6119399..6132415, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene N-acetylated alpha-linked acidic dipeptidase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45420 Neighboring gene SAC3 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E11014 Neighboring gene predicted gene, 57660 Neighboring gene microRNA 12193 Neighboring gene ADP-ribosylation factor-like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6141140-6141385 Neighboring gene predicted pseudogene 5510

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Feng T, et al. Mol Neurobiol, 2016 Aug. PMID 26115702, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026912.2 → NP_081188.1  sorting nexin-15

      See identical proteins and their annotated locations for NP_081188.1

      Status: VALIDATED

      Source sequence(s)
      AI850984, BC016091, BY289304
      Consensus CDS
      CCDS29495.1
      UniProtKB/Swiss-Prot
      Q91WE1
      Related
      ENSMUSP00000025702.8, ENSMUST00000025702.14
      Conserved Domains (2) summary
      cd02677
      Location:267 → 337
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl02563
      Location:9 → 126
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6169429..6182446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531831.5 → XP_006531894.1  sorting nexin-15 isoform X1

      See identical proteins and their annotated locations for XP_006531894.1

      UniProtKB/Swiss-Prot
      Q91WE1
      Conserved Domains (2) summary
      cd02677
      Location:267 → 337
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl02563
      Location:9 → 126
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. XM_011248651.4 → XP_011246953.1  sorting nexin-15 isoform X2

      UniProtKB/TrEMBL
      D3Z479
      Related
      ENSMUSP00000122740.2, ENSMUST00000154601.8
      Conserved Domains (1) summary
      cl02563
      Location:9 → 126
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WE1.1 GenPept UniProtKB/Swiss-Prot:Q91WE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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