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    Ttc17 tetratricopeptide repeat domain 17 [ Mus musculus (house mouse) ]

    Gene ID: 74569, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ttc17provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 17provided by MGI
    Primary source
    MGI:MGI:1921819
    See related
    Ensembl:ENSMUSG00000027194 AllianceGenome:MGI:1921819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D2Bwg1005e; 9130020K17Rik
    Summary
    Predicted to be involved in actin filament polymerization and cilium organization. Predicted to act upstream of or within cell projection organization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in actin cytoskeleton and cytoplasm. Orthologous to human TTC17 (tetratricopeptide repeat domain 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.7), colon adult (RPKM 4.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E1; 2 51.69 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (94131111..94237034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (94300766..94406710, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MIR670 host gene (non-protein coding) Neighboring gene microRNA 129-2 Neighboring gene microRNA 129b Neighboring gene microRNA 670 Neighboring gene STARR-seq mESC enhancer starr_05177 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 1 Neighboring gene RIKEN cDNA 2810002D19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr2:94278212-94278513 Neighboring gene apoptosis inhibitor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 17
    Names
    TPR repeat protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355690.1 → NP_001342619.1  tetratricopeptide repeat protein 17 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL672251, AL683878
      Consensus CDS
      CCDS89523.1
      Related
      ENSMUSP00000106868.3, ENSMUST00000111237.9
      Conserved Domains (5) summary
      COG0457
      Location:979 → 1136
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:621 → 647
      TPR; TPR repeat [structural motif]
      cd16269
      Location:379 → 390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26002
      Location:573 → 718
      TPR_11; TPR repeat

    2. NM_001355691.1 → NP_001342620.1  tetratricopeptide repeat protein 17 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL672251, AL683878
      Conserved Domains (4) summary
      sd00006
      Location:621 → 647
      TPR; TPR repeat [structural motif]
      cd16269
      Location:379 → 390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26002
      Location:573 → 718
      TPR_11; TPR repeat

    3. NM_183106.2 → NP_898929.2  tetratricopeptide repeat protein 17 isoform 1 precursor

      See identical proteins and their annotated locations for NP_898929.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI851013, AK018641, AK038364, AL683878, BE626951, BY358550, CA328748, CF536785, CJ180754
      Consensus CDS
      CCDS38185.1
      UniProtKB/Swiss-Prot
      E9PVB5, Q4VBE5, Q5RKR1
      Related
      ENSMUSP00000106869.2, ENSMUST00000111238.8
      Conserved Domains (6) summary
      smart00028
      Location:689 → 718
      TPR; Tetratricopeptide repeats
      sd00006
      Location:621 → 647
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:1145 → 1175
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:1111 → 1173
      TPR_11; TPR repeat
      cd16269
      Location:379 → 390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      94131111..94237034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500310.5 → XP_006500373.1  tetratricopeptide repeat protein 17 isoform X1

      Conserved Domains (5) summary
      COG0457
      Location:995 → 1152
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR02917
      Location:532 → 677
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:580 → 606
      TPR; TPR repeat [structural motif]
      cd16269
      Location:338 → 349
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:288 → 369
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_006500312.5 → XP_006500375.1  tetratricopeptide repeat protein 17 isoform X2

      UniProtKB/TrEMBL
      A2AFY7
      Related
      ENSMUSP00000092395.5, ENSMUST00000094801.5
      Conserved Domains (5) summary
      TIGR02917
      Location:573 → 718
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:621 → 647
      TPR; TPR repeat [structural motif]
      cd16269
      Location:379 → 390
      GBP_C; coiled coil [structural motif]
      pfam00515
      Location:297 → 328
      TPR_1; Tetratricopeptide repeat
      cl20817
      Location:329 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PVB5.1 GenPept UniProtKB/Swiss-Prot:E9PVB5

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