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    Grhpr glyoxylate reductase/hydroxypyruvate reductase [ Mus musculus (house mouse) ]

    Gene ID: 76238, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Grhprprovided by MGI
    Official Full Name
    glyoxylate reductase/hydroxypyruvate reductaseprovided by MGI
    Primary source
    MGI:MGI:1923488
    See related
    Ensembl:ENSMUSG00000035637 AllianceGenome:MGI:1923488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glxr; 1110059D05Rik; 6430629L09Rik
    Summary
    This gene encodes a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. The encoded protein catalyzes three enzymatic reactions: the conversion of hydroxypyruvate to D-glycerate as well as the reverse reaction, and the conversion of glyoxylate to glycolate. Homozygous knockout mice exhibit elevated synthesis of oxalate and glycerate. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in liver E18 (RPKM 121.1), kidney adult (RPKM 116.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B1; 4 23.65 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44981394..44990734)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44981394..44990734)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30763 Neighboring gene STARR-positive B cell enhancer ABC_E8808 Neighboring gene STARR-positive B cell enhancer ABC_E2110 Neighboring gene predicted gene 12679 Neighboring gene STARR-positive B cell enhancer ABC_E6170 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis. Zong C, et al. Pathol Res Pract, 2016 May. PMID 26997491
    2. Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity. Wood KD, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Sep 1. PMID 31055082, Free PMC Article
    3. Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Knight J, et al. Am J Physiol Renal Physiol, 2012 Mar 15. PMID 22189945, Free PMC Article
    4. Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha. Genolet R, et al. J Biol Chem, 2005 Jun 24. PMID 15840574
    5. The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria. Buchalski B, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Mar 1. PMID 31821850, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggested that GRHPR might exert its pro-apoptosis function in intestinal epithelial cells. Thus, GRHPR might play an important role in regulating IECs apoptosis, and might be a potential therapeutic target for Crohn's disease.
      Title: Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
    2. data indicate a species-specific regulation by PPARalpha of GRHPR, a key gene of the glyoxylate cycle
      Title: Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxylate reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydroxypyruvate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxypyruvate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dicarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glyoxylate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glyoxylate reductase/hydroxypyruvate reductase
    NP_001299809.1
    NP_525028.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312880.1 → NP_001299809.1  glyoxylate reductase/hydroxypyruvate reductase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR, resulting in the use of a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK004307, AK018293, AL824706, BB869843, CF738475
      Conserved Domains (2) summary
      COG1052
      Location:1 → 182
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cl21454
      Location:1 → 174
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_080289.2 → NP_525028.1  glyoxylate reductase/hydroxypyruvate reductase isoform 1

      See identical proteins and their annotated locations for NP_525028.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK004307, AL824706, BB869843, CF738475
      Consensus CDS
      CCDS18128.1
      UniProtKB/Swiss-Prot
      Q91Z53
      UniProtKB/TrEMBL
      Q3T9Z2
      Related
      ENSMUSP00000047218.7, ENSMUST00000045078.13
      Conserved Domains (2) summary
      COG1052
      Location:1 → 327
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:7 → 319
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      44981394..44990734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Z53.1 GenPept UniProtKB/Swiss-Prot:Q91Z53

    Gene LinkOut

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