Nup155 nucleoporin 155 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nup155provided by MGI
Official Full Name: nucleoporin 155provided by MGI
Primary source: MGI:MGI:2181182
See related: Ensembl:ENSMUSG00000022142 AllianceGenome:MGI:2181182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0791; D930027M19Rik
Summary: Predicted to be a structural constituent of nuclear pore. Acts upstream of or within atrial cardiac muscle cell action potential; mRNA export from nucleus; and protein import into nucleus. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human NUP155 (nucleoporin 155). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.0), limb E14.5 (RPKM 8.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.82 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (8135861..8189343)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (8109263..8159859)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NUP155 regulates cardioplasticity of a sub-network embedded within a larger framework of genome integrity, and exemplifies how transcriptome cardiogenicity in an embryonic stem cell genome is recalibrated by nucleoporin dysfunction
Title: NUP155 insufficiency recalibrates a pluripotent transcriptome with network remodeling of a cardiogenic signaling module.
These human and mouse studies indicate that loss of NUP155 function causes atrial fibrillation by altering mRNA and protein transport and link the nuclear pore complex to cardiovascular disease.
Title: Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within atrial cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore inner ring	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear pore complex protein Nup155

Names: 155 kDa nucleoporin; nucleoporin Nup155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133227.3 → NP_573490.3 nuclear pore complex protein Nup155

See identical proteins and their annotated locations for NP_573490.3

Status: VALIDATED

Source sequence(s)

AK086426, AK129217, CO040753, CO433695

Consensus CDS

CCDS37034.1

UniProtKB/Swiss-Prot

Q99P88

UniProtKB/TrEMBL

Q80X48

Related

ENSMUSP00000128819.2, ENSMUST00000163765.3

Conserved Domains (2) summary

pfam03177
Location:1008 → 1213

Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

pfam08801
Location:77 → 507

Nucleoporin_N; Nup133 N terminal like