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    Cuedc1 CUE domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 103841, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cuedc1provided by MGI
    Official Full Name
    CUE domain containing 1provided by MGI
    Primary source
    MGI:MGI:2144281
    See related
    Ensembl:ENSMUSG00000018378 AllianceGenome:MGI:2144281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330016O16Rik
    Summary
    Predicted to enable ubiquitin binding activity. Is expressed in intestine smooth muscle circular layer. Orthologous to human CUEDC1 (CUE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.2), bladder adult (RPKM 20.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 C; 11 52.4 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87989972..88084966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88099146..88194140)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30308 Neighboring gene serine and arginine-rich splicing factor 1 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene STARR-seq mESC enhancer starr_30316 Neighboring gene STARR-positive B cell enhancer ABC_E8441 Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88047672-88047825 Neighboring gene STARR-positive B cell enhancer ABC_E7041 Neighboring gene predicted gene, 38534 Neighboring gene VISTA enhancer mm439 Neighboring gene predicted gene, 34366

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
    2. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article
    3. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    CUE domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172099.1 → NP_001165570.1  CUE domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The 5' UTR for this variant has not been determined. The resulting isoform (2) includes a three amino acid segment near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AL593853
      UniProtKB/TrEMBL
      B7ZNF1
      Conserved Domains (1) summary
      cd14366
      Location:50 → 91
      CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

    2. NM_198013.3 → NP_932130.2  CUE domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_932130.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AK049250, BC131989, CF950088, CJ113091, CJ118464, CK332869, EL962896
      Consensus CDS
      CCDS25226.1
      UniProtKB/Swiss-Prot
      Q5SXC2, Q8R3V6
      UniProtKB/TrEMBL
      A2RS63
      Related
      ENSMUSP00000018522.7, ENSMUST00000018522.13
      Conserved Domains (1) summary
      cd14366
      Location:50 → 91
      CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87989972..88084966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3V6.2 GenPept UniProtKB/Swiss-Prot:Q8R3V6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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