Tnnt3 troponin T3, skeletal, fast [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnnt3provided by MGI
Official Full Name: troponin T3, skeletal, fastprovided by MGI
Primary source: MGI:MGI:109550
See related: Ensembl:ENSMUSG00000061723 AllianceGenome:MGI:109550
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: fTnT
Summary: Predicted to enable calcium-dependent protein binding activity and cytoskeletal protein binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in several processes, including positive regulation of calcium-dependent ATPase activity; regulation of ATPase activity; and sarcomere organization. Predicted to be part of troponin complex. Is expressed in several structures, including diaphragm; eyelid epithelium; lower jaw; musculature; and urinary system. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 50.5), bladder adult (RPKM 9.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.94 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142052530..142069746)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (142498771..142516213)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TnT3 regulates expression of Cav1.1 in skeletal muscle, this regulation is impaired in aging.
Title: Will you still need me (Ca(2+) , TnT, and DHPR), will you still cleave me (calpain), when I'm 64?
TnT3 regulates transcription of Cacna1s, the gene encoding Cav1.1. Knocking down TnT3 in vivo downregulated Cav1.1.
Title: Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice.
TnT3 facilitates Cavbeta1a nuclear recruitment, suggesting that the two proteins play a heretofore unknown role during early muscle differentiation in addition to their classical role in excitation-contraction coupling regulation.
Title: Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle.
On the basis of these results, it was proposed that aberrant fTnT represents a biological marker of muscle phenotype severity and disease progression.
Title: Altered Tnnt3 characterizes selective weakness of fast fibers in mice overexpressing FSHD region gene 1 (FRG1).
Data conclude that TnT3 contains both a nuclear localization signal and a DNA-binding domain, which may mediate nuclear/nucleolar signaling and muscle cell apoptosis.
Title: Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis.
fast skeletal muscle troponin activation increases force at submaximal activation in both wildtype and NEB knockout fiber bundles.
Title: Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.
results showed dominantly negative effects of coexistence of fast skeletal muscle TnT and cardiac TnT on contractile kinetics absent the influence of extracellular matrix; a dilatative remodeling at the cellular level was observed, supporting a pathological significance
Title: Chronic coexistence of two troponin T isoforms in adult transgenic mouse cardiomyocytes decreased contractile kinetics and caused dilatative remodeling.
The findings suggested that effects of muscle load on Tnnt3 pre-mRNA alternative splicing are controlled by a cell-autonomous mechanism, rather than systemically.
Title: Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch.
Data suggest that AMPK emerges as a possibly important regulator of cardiac and skeletal contractility via phosphorylation of a preferred site adjacent to the inhibitory loop of the thin filament protein TnI.
Title: A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tnnt3 (e-PCR), detects polymorphism
- UniSTS:547474

L49466 (e-PCR)
- UniSTS:179678

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to actin binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to tropomyosin binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info
enables troponin C binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin C binding	ISO Inferred from Sequence Orthology more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of calcium-dependent ATPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: troponin T, fast skeletal muscle

Names: fast skeletal muscle troponin T; fast skeletal muscle troponin T3; skeletal muscle fast-twitch TnT; tnTf

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163664.1 → NP_001157136.1 troponin T, fast skeletal muscle isoform 1

See identical proteins and their annotated locations for NP_001157136.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AI037743, AI173874, AI574395, CK791812, DV049834

Consensus CDS

CCDS52452.1

UniProtKB/TrEMBL

J3QP61, Z4YNB2

Related

ENSMUSP00000136278.2, ENSMUST00000179658.8

Conserved Domains (1) summary

pfam00992
Location:76 → 211

Troponin
NM_001163665.1 → NP_001157137.1 troponin T, fast skeletal muscle isoform 2

See identical proteins and their annotated locations for NP_001157137.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (2) is the same size but has an alternate internal segment compared to isoform 1.

Source sequence(s)

AI037743, AI173874, AI574395, CB196352, DV049834

Consensus CDS

CCDS52451.1

UniProtKB/TrEMBL

A0A0R4J1B0, J3QP61

Related

ENSMUSP00000101578.4, ENSMUST00000105958.10

Conserved Domains (1) summary

pfam00992
Location:76 → 211

Troponin
NM_001163666.1 → NP_001157138.1 troponin T, fast skeletal muscle isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AI037743, AI746973, CK791812, DV049834

Consensus CDS

CCDS52456.1

UniProtKB/TrEMBL

Z4YKG8, Z4YKH8

Related

ENSMUSP00000101574.4, ENSMUST00000105954.10

Conserved Domains (1) summary

pfam00992
Location:67 → 202

Troponin
NM_001163667.1 → NP_001157139.1 troponin T, fast skeletal muscle isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AI037743, BY766323, CK791812, DV049834

Consensus CDS

CCDS52454.1

UniProtKB/Swiss-Prot

A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47

UniProtKB/TrEMBL

Z4YJU0

Related

ENSMUSP00000077587.9, ENSMUST00000078497.15

Conserved Domains (1) summary

pfam00992
Location:72 → 207

Troponin
NM_001163668.1 → NP_001157140.1 troponin T, fast skeletal muscle isoform 6

See identical proteins and their annotated locations for NP_001157140.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AA771596, AI037743, CK791812, DV049834, U77779

Consensus CDS

CCDS52455.1

UniProtKB/TrEMBL

A2A6H6, Z4YKH8

Related

ENSMUSP00000101575.2, ENSMUST00000105955.8

Conserved Domains (1) summary

pfam00992
Location:59 → 195

Troponin
NM_001163669.1 → NP_001157141.1 troponin T, fast skeletal muscle isoform 5

See identical proteins and their annotated locations for NP_001157141.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AA028290, AI037743, CK791812, DV049834

Consensus CDS

CCDS52453.1

UniProtKB/TrEMBL

Z4YKF8, Z4YKH8

Related

ENSMUSP00000101572.4, ENSMUST00000105952.10

Conserved Domains (1) summary

pfam00992
Location:63 → 199

Troponin
NM_001163670.1 → NP_001157142.1 troponin T, fast skeletal muscle isoform 8

See identical proteins and their annotated locations for NP_001157142.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks four alternate in-frame exons compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AA754928, AI037743, AK003147, DV049834

Consensus CDS

CCDS52457.1

UniProtKB/TrEMBL

A2A6J0, Z4YKH8

Related

ENSMUSP00000101569.2, ENSMUST00000105949.8

Conserved Domains (1) summary

pfam00992
Location:48 → 184

Troponin
NM_001347546.1 → NP_001334475.1 troponin T, fast skeletal muscle isoform 9

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

Consensus CDS

CCDS85475.1

UniProtKB/TrEMBL

Z4YKE7, Z4YKG3

Related

ENSMUSP00000101573.4, ENSMUST00000105953.10

Conserved Domains (1) summary

pfam00992
Location:66 → 201

Troponin
NM_001347547.1 → NP_001334476.1 troponin T, fast skeletal muscle isoform 10

Status: VALIDATED

Description

Transcript Variant: This variant (10) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

Consensus CDS

CCDS85471.1

UniProtKB/TrEMBL

A0A0R4J1A8, Z4YKH8

Related

ENSMUSP00000127854.3, ENSMUST00000169299.9

Conserved Domains (1) summary

pfam00992
Location:58 → 194

Troponin
NM_001347548.1 → NP_001334477.1 troponin T, fast skeletal muscle isoform 11

Status: VALIDATED

Description

Transcript Variant: This variant (11) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (11) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

Consensus CDS

CCDS85473.1

UniProtKB/TrEMBL

A2A6J1, Z4YKH8

Related

ENSMUSP00000101564.2, ENSMUST00000105944.3

Conserved Domains (1) summary

pfam00992
Location:54 → 190

Troponin
NM_001347549.1 → NP_001334478.1 troponin T, fast skeletal muscle isoform 12

Status: VALIDATED

Description

Transcript Variant: This variant (12) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (12) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

Consensus CDS

CCDS85472.1

UniProtKB/TrEMBL

A2A6I0, Z4YKH8

Related

ENSMUSP00000101568.2, ENSMUST00000105948.8

Conserved Domains (1) summary

pfam00992
Location:54 → 190

Troponin
NM_001347550.1 → NP_001334479.1 troponin T, fast skeletal muscle isoform 13

Status: VALIDATED

Description

Transcript Variant: This variant (13) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (13) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

Consensus CDS

CCDS85474.1

UniProtKB/TrEMBL

A2A6I3, Z4YKH8

Related

ENSMUSP00000101561.2, ENSMUST00000105941.8

Conserved Domains (1) summary

pfam00992
Location:52 → 188

Troponin
NM_001347551.1 → NP_001334480.1 troponin T, fast skeletal muscle isoform 14

Status: VALIDATED

Description

Transcript Variant: This variant (14) lacks five alternate in-frame exons compared to variant 1. The resulting isoform (14) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

Consensus CDS

CCDS85477.1

UniProtKB/TrEMBL

A2A6I8, Z4YKH8

Related

ENSMUSP00000101562.2, ENSMUST00000105942.8

Conserved Domains (1) summary

pfam00992
Location:43 → 178

Troponin
NM_001347552.1 → NP_001334481.1 troponin T, fast skeletal muscle isoform 15

Status: VALIDATED

Description

Transcript Variant: This variant (15) lacks six alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (15) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

Consensus CDS

CCDS85476.1

UniProtKB/TrEMBL

A2A6I5, Z4YKH8

Related

ENSMUSP00000101563.2, ENSMUST00000105943.8

Conserved Domains (1) summary

pfam00992
Location:43 → 178

Troponin
NM_001360157.1 → NP_001347086.1 troponin T, fast skeletal muscle isoform 16

Status: VALIDATED

Description

Transcript Variant: This variant (16) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (16) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:61 → 196

Troponin
NM_001360158.1 → NP_001347087.1 troponin T, fast skeletal muscle isoform 17

Status: VALIDATED

Description

Transcript Variant: This variant (17) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (17) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL603651

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:59 → 195

Troponin
NM_011620.3 → NP_035750.2 troponin T, fast skeletal muscle isoform 7

See identical proteins and their annotated locations for NP_035750.2

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AI037743, AI322331, DV049834, U77779

Consensus CDS

CCDS22031.1

UniProtKB/TrEMBL

A0A0R4J1B1, Z4YKH8

Related

ENSMUSP00000073815.7, ENSMUST00000074187.13

Conserved Domains (1) summary

pfam00992
Location:52 → 188

Troponin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

142052530..142069746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508584.2 → XP_006508647.1 troponin T, fast skeletal muscle isoform X5

See identical proteins and their annotated locations for XP_006508647.1

UniProtKB/TrEMBL

Z4YKD9, Z4YKH8

Related

ENSMUSP00000101567.2, ENSMUST00000105947.8

Conserved Domains (1) summary

pfam00992
Location:63 → 199

Troponin
XM_006508588.2 → XP_006508651.1 troponin T, fast skeletal muscle isoform X10

See identical proteins and their annotated locations for XP_006508651.1

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:58 → 194

Troponin
XM_036152902.1 → XP_036008795.1 troponin T, fast skeletal muscle isoform X8

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:58 → 194

Troponin
XM_036152896.1 → XP_036008789.1 troponin T, fast skeletal muscle isoform X1

UniProtKB/Swiss-Prot

A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47

Conserved Domains (1) summary

pfam00992
Location:71 → 207

Troponin
XM_036152903.1 → XP_036008796.1 troponin T, fast skeletal muscle isoform X9

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:58 → 194

Troponin
XM_036152904.1 → XP_036008797.1 troponin T, fast skeletal muscle isoform X13

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:53 → 189

Troponin
XM_036152905.1 → XP_036008798.1 troponin T, fast skeletal muscle isoform X14

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:53 → 189

Troponin
XM_036152908.1 → XP_036008801.1 troponin T, fast skeletal muscle isoform X17

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:49 → 185

Troponin
XM_036152898.1 → XP_036008791.1 troponin T, fast skeletal muscle isoform X3

UniProtKB/Swiss-Prot

A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47

Conserved Domains (1) summary

pfam00992
Location:70 → 206

Troponin
XM_036152901.1 → XP_036008794.1 troponin T, fast skeletal muscle isoform X7

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:61 → 197

Troponin
XM_036152909.1 → XP_036008802.1 troponin T, fast skeletal muscle isoform X18

UniProtKB/TrEMBL

Z4YKH8

Related

ENSMUSP00000116087.2, ENSMUST00000146804.8

Conserved Domains (1) summary

pfam00992
Location:48 → 184

Troponin
XM_036152897.1 → XP_036008790.1 troponin T, fast skeletal muscle isoform X2

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:70 → 206

Troponin
XM_006508591.2 → XP_006508654.1 troponin T, fast skeletal muscle isoform X12

See identical proteins and their annotated locations for XP_006508654.1

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:57 → 193

Troponin
XM_006508590.2 → XP_006508653.1 troponin T, fast skeletal muscle isoform X11

See identical proteins and their annotated locations for XP_006508653.1

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:57 → 193

Troponin
XM_036152906.1 → XP_036008799.1 troponin T, fast skeletal muscle isoform X15

UniProtKB/TrEMBL

A0A0R4J1B1, Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:52 → 188

Troponin
XM_036152899.1 → XP_036008792.1 troponin T, fast skeletal muscle isoform X4

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:65 → 201

Troponin
XM_036152907.1 → XP_036008800.1 troponin T, fast skeletal muscle isoform X16

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:52 → 188

Troponin
XM_036152911.1 → XP_036008804.1 troponin T, fast skeletal muscle isoform X20

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:47 → 183

Troponin
XM_036152910.1 → XP_036008803.1 troponin T, fast skeletal muscle isoform X19

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:47 → 183

Troponin
XM_036152900.1 → XP_036008793.1 troponin T, fast skeletal muscle isoform X6

UniProtKB/TrEMBL

Z4YKH8

Conserved Domains (1) summary

pfam00992
Location:61 → 197

Troponin