Cers4 ceramide synthase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cers4provided by MGI
Official Full Name: ceramide synthase 4provided by MGI
Primary source: MGI:MGI:1914510
See related: Ensembl:ENSMUSG00000008206 AllianceGenome:MGI:1914510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trh1; Lass4; 2900019C14Rik
Summary: Enables sphingosine N-acyltransferase activity. Acts upstream of or within ceramide biosynthetic process. Located in endoplasmic reticulum. Is expressed in nervous system; nose; oral epithelium; and skin. Orthologous to human CERS4 (ceramide synthase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 11.0), lung adult (RPKM 8.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 2.04 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (4542863..4579603)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (4492818..4529603)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
Title: T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.
Title: Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.
CerS4-directed epidermal ceramide composition is essential to control hair follicle stem and progenitor cell behavior potentially through its regulation of BMP and Wnt signaling
Title: Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.
Loss of CerS4 protein leads to an altered lipid composition of the sebum, which is more solidified and therefore might cause progressive hair loss due to physical blocking of the hair canal.
Title: Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.
Title: Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.
Lag1p family members trh1 and trh4 regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids
Title: Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables sphingosine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sphingosine N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ceramide synthase 4

Names: LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; TRAM homolog 1; longevity assurance homolog 4; sphingosine N-acyltransferase CERS4; translocating chain-associating membrane protein homolog 1

NP_080334.3

EC 2.3.1.24

XP_006508924.1

EC 2.3.1.24

XP_006508925.1

EC 2.3.1.24

XP_006508926.1

EC 2.3.1.24

XP_030099592.1

EC 2.3.1.24

XP_036010142.1

EC 2.3.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026058.4 → NP_080334.3 ceramide synthase 4

See identical proteins and their annotated locations for NP_080334.3

Status: VALIDATED

Source sequence(s)

AK028937, AK076409, AV360657, BB006809, CK617511

Consensus CDS

CCDS22086.1

UniProtKB/Swiss-Prot

Q8BZA6, Q8C151, Q9CX09, Q9D6J1

Related

ENSMUSP00000008350.9, ENSMUST00000008350.16

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

4542863..4579603

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243732.2 → XP_030099592.1 ceramide synthase 4 isoform X1

UniProtKB/Swiss-Prot

Q8BZA6, Q8C151, Q9CX09, Q9D6J1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_006508861.4 → XP_006508924.1 ceramide synthase 4 isoform X1

See identical proteins and their annotated locations for XP_006508924.1

UniProtKB/Swiss-Prot

Q8BZA6, Q8C151, Q9CX09, Q9D6J1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_006508863.4 → XP_006508926.1 ceramide synthase 4 isoform X1

See identical proteins and their annotated locations for XP_006508926.1

UniProtKB/Swiss-Prot

Q8BZA6, Q8C151, Q9CX09, Q9D6J1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_036154249.1 → XP_036010142.1 ceramide synthase 4 isoform X1

UniProtKB/Swiss-Prot

Q8BZA6, Q8C151, Q9CX09, Q9D6J1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_006508862.5 → XP_006508925.1 ceramide synthase 4 isoform X1

See identical proteins and their annotated locations for XP_006508925.1

UniProtKB/Swiss-Prot

Q8BZA6, Q8C151, Q9CX09, Q9D6J1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.