Tada3 transcriptional adaptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tada3provided by MGI
Official Full Name: transcriptional adaptor 3provided by MGI
Primary source: MGI:MGI:1915724
See related: Ensembl:ENSMUSG00000048930 AllianceGenome:MGI:1915724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADA3; Tada3l; 1110004B19Rik
Summary: Enables nuclear receptor coactivator activity. Acts upstream of or within mitotic cell cycle; regulation of protein modification process; and regulation of protein stability. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in eye; ureteric tip; and ureteric trunk. Orthologous to human TADA3 (transcriptional adaptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 16.2), CNS E18 (RPKM 14.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.75 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113343594..113354799, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113366633..113377838, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings demonstrate that acetylation of ADA3 by its associated histone acetyltransferases is essential for its key role in histone acetylation and cell cycle progression.
Title: Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation.
demonstrate a novel ADA3 interaction with CENP-B-centromere that may account for its previously known function in mitosis
Title: Alteration/Deficiency in Activation 3 (ADA3) Protein, a Cell Cycle Regulator, Associates with the Centromere through CENP-B and Regulates Chromosome Segregation.
The loss of Ada3 led to enhanced chromosomal aberrations, such as chromosome breaks, fragments, deletions and translocations, which further increased upon DNA damage.
Title: Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability.
a critical role of Ada3 in embryogenesis and cell cycle progression as an essential component of HAT complex.
Title: Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

BB284401 (e-PCR)
- UniSTS:208013

MARC_26162-26163:1030455175:1 (e-PCR)
- UniSTS:268964

PMC117179P1 (e-PCR)
- UniSTS:270317

UniSTS:238061 (e-PCR)
- UniSTS:238061

AI987856 (e-PCR)
- UniSTS:164336

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of RNA splicing	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of tubulin deacetylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcriptional adapter 3

Names: ADA3 homolog; ADA3-like protein; mADA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372392.1 → NP_001359321.1 transcriptional adapter 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC155287

Related

ENSMUSP00000043363.3, ENSMUST00000043333.9

Conserved Domains (1) summary

pfam10198
Location:317 → 430

Ada3; Histone acetyltransferases subunit 3
NM_001372393.1 → NP_001359322.1 transcriptional adapter 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC155287

Conserved Domains (1) summary

pfam10198
Location:317 → 430

Ada3; Histone acetyltransferases subunit 3
NM_133932.3 → NP_598693.1 transcriptional adapter 3 isoform 1

See identical proteins and their annotated locations for NP_598693.1

Status: VALIDATED

Source sequence(s)

AC155287

Consensus CDS

CCDS20416.1

UniProtKB/Swiss-Prot

Q8CIH4, Q8K289, Q8R0L9, Q8R5E3, Q9CTJ0

Related

ENSMUSP00000032410.8, ENSMUST00000032410.14

Conserved Domains (1) summary

pfam10198
Location:309 → 422

Ada3; Histone acetyltransferases subunit 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

113343594..113354799 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165703.1 → XP_036021596.1 transcriptional adapter 3 isoform X1

Conserved Domains (1) summary

pfam10198
Location:317 → 430

Ada3; Histone acetyltransferases subunit 3