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    Itgae integrin alpha E, epithelial-associated [ Mus musculus (house mouse) ]

    Gene ID: 16407, updated on 26-Jul-2021

    Summary

    Official Symbol
    Itgaeprovided by MGI
    Official Full Name
    integrin alpha E, epithelial-associatedprovided by MGI
    Primary source
    MGI:MGI:1298377
    See related
    Ensembl:ENSMUSG00000005947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    alph; CD103; aM290; alpha-E1; A530055J10; alpha-M290
    Expression
    Biased expression in thymus adult (RPKM 6.0), testis adult (RPKM 5.9) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Itgae in Genome Data Viewer
    Location:
    11 B4; 11 45.22 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72981335..73038425)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73090505..73147449)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (72904097..72960951)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha Neighboring gene nuclear cap binding subunit 3 Neighboring gene histone H3 associated protein kinase Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene ER membrane protein complex subunit 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC183601

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    integrin alpha-E
    Names
    integrin alpha M290

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361245.1NP_001348174.1  integrin alpha-E isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL670399
      Conserved Domains (3) summary
      smart00191
      Location:565624
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:195370
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:667938
      Integrin_alpha2; Integrin alpha
    2. NM_008399.3NP_032425.2  integrin alpha-E isoform 1 precursor

      See identical proteins and their annotated locations for NP_032425.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK040983, AL670399, AV204610, BF453582, CF983010
      Consensus CDS
      CCDS24995.1
      UniProtKB/Swiss-Prot
      Q60677
      UniProtKB/TrEMBL
      Q8BS01
      Related
      ENSMUSP00000006101.4, ENSMUST00000006101.4
      Conserved Domains (3) summary
      smart00191
      Location:566625
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:196371
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:668939
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72981335..73038425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156348.1XP_036012241.1  integrin alpha-E isoform X1

      Conserved Domains (3) summary
      smart00191
      Location:566624
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:196371
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:667938
      Integrin_alpha2; Integrin alpha

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172944.2: Suppressed sequence

      Description
      NM_172944.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
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