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    Egf epidermal growth factor [ Mus musculus (house mouse) ]

    Gene ID: 13645, updated on 8-Jun-2021

    Summary

    Official Symbol
    Egfprovided by MGI
    Official Full Name
    epidermal growth factorprovided by MGI
    Primary source
    MGI:MGI:95290
    See related
    Ensembl:ENSMUSG00000028017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI790464
    Summary
    This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]
    Expression
    Restricted expression toward kidney adult (RPKM 187.5) See more
    Orthologs
    NEW
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    Genomic context

    See Egf in Genome Data Viewer
    Location:
    3 G3; 3 58.5 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129471223..129548971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129677574..129755322, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (129380493..129458240, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 7 Neighboring gene predicted gene, 35986 Neighboring gene ELOVL family member 6, elongation of long chain fatty acids (yeast) Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene predicted gene, 36130 Neighboring gene retinal pigment epithelium derived rhodopsin homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway via MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    pro-epidermal growth factor
    Names
    Pro-epidermal growth factor precursor (EGF)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310737.1NP_001297666.1  pro-epidermal growth factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC098732, AK136439, AK157778, BP761200
      Consensus CDS
      CCDS80020.1
      UniProtKB/TrEMBL
      A0A0G2JF92, Q3UWD7
      Related
      ENSMUSP00000143075.2, ENSMUST00000197079.5
      Conserved Domains (5) summary
      PHA02887
      Location:481518
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:95138
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07001
      Location:609700
      BAT2_N; BAT2 N-terminus
      pfam07645
      Location:376416
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:250285
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. NM_001329594.1NP_001316523.1  pro-epidermal growth factor isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC098732, AK085707, BB635280, BP761200
      Consensus CDS
      CCDS89687.1
      UniProtKB/TrEMBL
      A0A0G2JDT8
      Related
      ENSMUSP00000142497.2, ENSMUST00000199615.5
    3. NM_010113.4NP_034243.2  pro-epidermal growth factor isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_034243.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC098732, AK136439, BP761200
      Consensus CDS
      CCDS17833.1
      UniProtKB/Swiss-Prot
      P01132
      UniProtKB/TrEMBL
      Q3UWD7
      Related
      ENSMUSP00000029653.3, ENSMUST00000029653.7
      Conserved Domains (5) summary
      PHA02887
      Location:9821019
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:596639
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:877917
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:449482
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:358399
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      129471223..129548971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500990.5XP_006501053.1  pro-epidermal growth factor isoform X3

      Conserved Domains (4) summary
      PHA02887
      Location:941978
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:596639
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:877917
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:366401
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. XM_011240011.4XP_011238313.1  pro-epidermal growth factor isoform X2

      Conserved Domains (4) summary
      PHA02887
      Location:945982
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:600643
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:881921
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:370405
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    3. XM_011240010.4XP_011238312.1  pro-epidermal growth factor isoform X1

      Conserved Domains (4) summary
      PHA02887
      Location:9861023
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:600643
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:881921
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:370405
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RNA

    1. XR_004941277.1 RNA Sequence

    2. XR_001783650.3 RNA Sequence

    3. XR_004941276.1 RNA Sequence

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