Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Oprl1 opioid receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 18389, updated on 23-Jun-2021

    Summary

    Official Symbol
    Oprl1provided by MGI
    Official Full Name
    opioid receptor-like 1provided by MGI
    Primary source
    MGI:MGI:97440
    See related
    Ensembl:ENSMUSG00000027584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    O; XO; mo; MOR; NOP; KOR3; LC13; ORGC; ORL1; Oprl; XOR1; morc; KOR-3; LC132; MOR-C
    Summary
    The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in whole brain E14.5 (RPKM 16.2), CNS E18 (RPKM 14.7) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Oprl1 in Genome Data Viewer
    Location:
    2 H4; 2 103.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181356585..181362778)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181715000..181720985)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (181449749..181455677)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 19 Neighboring gene LKAAEAR motif containing 1 (IKAAEAR murine motif) Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene myelin transcription factor 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled opioid receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nociceptin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nociceptin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables nociceptin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in conditioned place preference ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of locomotor rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nociceptin receptor
    Names
    K3 opiate receptor
    N/OFQ receptor
    kappa-type 3 opioid receptor
    nociceptin/ orphaninFQ receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252565.1NP_001239494.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_001239494.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' non-coding exon; therefore, differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK038620, AL845173
      Consensus CDS
      CCDS17222.1
      UniProtKB/Swiss-Prot
      P35377
      UniProtKB/TrEMBL
      Q542U1
      Related
      ENSMUSP00000104399.2, ENSMUST00000108768.8
      Conserved Domains (1) summary
      cd15092
      Location:49327
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001318919.1NP_001305848.1  nociceptin receptor isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AL845173, BC050885, BY267034
      Consensus CDS
      CCDS89611.1
      UniProtKB/Swiss-Prot
      P35377
      Related
      ENSMUSP00000159197.2, ENSMUST00000238942.2
      Conserved Domains (2) summary
      pfam00001
      Location:65316
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:63185
      7tm_4; Olfactory receptor
    3. NM_001318920.1NP_001305849.1  nociceptin receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as KOR-3d) uses an alternate, in-frame donor splice site at the first coding exon compared to variant 1. The resulting isoform (2) is shorter, missing a 5 aa protein segment compared to isoform 1.
      Source sequence(s)
      AF126469, AL845173, BC050885
      UniProtKB/Swiss-Prot
      P35377
      Conserved Domains (1) summary
      cd15092
      Location:49322
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001318922.1NP_001305851.1  nociceptin receptor isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as KOR-3a) contains an additional internal exon, which results in translation initiation from an alternate start codon compared to variant 1. The encoded isoform (3) is shorter with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK043275, AL845173, BY267034
      Consensus CDS
      CCDS84606.1
      UniProtKB/TrEMBL
      B0R0C0
      Related
      ENSMUSP00000104394.2, ENSMUST00000108763.8
      Conserved Domains (2) summary
      cd14964
      Location:7091
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:61313
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    5. NM_001318923.1NP_001305852.1  nociceptin receptor isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate donor splice site and contains an additional internal exon, which results in translation initiation from an alternate start codon compared to variant 1. The encoded isoform (4) is shorter with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK044178, AL845173, BY267034
      Conserved Domains (2) summary
      cd14964
      Location:6586
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:56308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    6. NM_001318924.1NP_001305853.1  nociceptin receptor isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as KOR-3b) contains an additional internal exon, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1. Variants 6 and 7 encode the same isoform.
      Source sequence(s)
      AK031926, AL845173, BU708032
      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    7. NM_001318925.1NP_001305854.1  nociceptin receptor isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as KOR-3c) contains an additional internal exon, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1. Variants 6 and 7 encode the same isoform.
      Source sequence(s)
      AK031926, AL845173, BY267034
      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    8. NM_011012.5NP_035142.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_035142.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AL845173, BC050885, BY267034
      Consensus CDS
      CCDS17222.1
      UniProtKB/Swiss-Prot
      P35377
      UniProtKB/TrEMBL
      Q542U1
      Related
      ENSMUSP00000071513.4, ENSMUST00000071585.10
      Conserved Domains (1) summary
      cd15092
      Location:49327
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_134926.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two consecutive internal exons compared to variant 1. It is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK142474, AL845173, BY267034
      Related
      ENSMUST00000126835.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181356585..181362778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248361.2XP_030104221.1  nociceptin receptor isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:7091
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:61313
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_017316325.2XP_017171814.1  nociceptin receptor isoform X1

      UniProtKB/Swiss-Prot
      P35377
      UniProtKB/TrEMBL
      Q542U1
      Conserved Domains (1) summary
      cd15092
      Location:49327
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_036159470.1XP_036015363.1  nociceptin receptor isoform X2

      Conserved Domains (1) summary
      cd15092
      Location:49322
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. XM_036159475.1XP_036015368.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    5. XM_030248363.2XP_030104223.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    6. XM_030248365.2XP_030104225.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    7. XM_017316329.3XP_017171818.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    8. XM_006500582.4XP_006500645.1  nociceptin receptor isoform X2

      See identical proteins and their annotated locations for XP_006500645.1

      UniProtKB/Swiss-Prot
      P35377
      Conserved Domains (1) summary
      cd15092
      Location:49322
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. XM_006500584.3XP_006500647.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    10. XM_036159476.1XP_036015369.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    11. XM_017316330.1XP_017171819.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    12. XM_030248366.1XP_030104226.1  nociceptin receptor isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:531
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1249
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Support Center