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    Slc22a1 solute carrier family 22 (organic cation transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20517, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slc22a1provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 1provided by MGI
    Primary source
    MGI:MGI:108111
    See related
    Ensembl:ENSMUSG00000023829
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lx; Or; Lx1; Oct; Orc; Oct1; Orct; Orct1
    Expression
    Biased expression in liver adult (RPKM 210.5), kidney adult (RPKM 182.5) and 4 other tissues See more
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    Genomic context

    See Slc22a1 in Genome Data Viewer
    Location:
    17 A1; 17 8.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12867761..12894725, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12648874..12675838, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (12841740..12868704, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 3 Neighboring gene RIKEN cDNA C030013G03 gene Neighboring gene solute carrier family 22 (organic cation transporter), member 2 Neighboring gene insulin-like growth factor 2 receptor Neighboring gene antisense Igf2r RNA Neighboring gene VISTA enhancer mm89

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC14019

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dopamine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotransmitter transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables norepinephrine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables organic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyrimidine nucleoside transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pyrimidine nucleoside transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables quaternary ammonium group transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables secondary active organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of transmembrane electrochemical gradient ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in quaternary ammonium group transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in toxin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 1
    Names
    mOCT1
    organic cation transporter 1
    solute carrier family 22, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009202.5NP_033228.2  solute carrier family 22 member 1

      See identical proteins and their annotated locations for NP_033228.2

      Status: PROVISIONAL

      Source sequence(s)
      AC167817
      Consensus CDS
      CCDS28393.1
      UniProtKB/Swiss-Prot
      O08966
      Related
      ENSMUSP00000024596.9, ENSMUST00000024596.10
      Conserved Domains (2) summary
      cd06174
      Location:125515
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      12867761..12894725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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