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    Slc22a23 solute carrier family 22, member 23 [ Mus musculus (house mouse) ]

    Gene ID: 73102, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc22a23provided by MGI
    Official Full Name
    solute carrier family 22, member 23provided by MGI
    Primary source
    MGI:MGI:1920352
    See related
    Ensembl:ENSMUSG00000038267 AllianceGenome:MGI:1920352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110004L20Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in blood vessel; branchial arch; embryo; heart; and outflow tract. Orthologous to human SLC22A23 (solute carrier family 22 member 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 22.2), kidney adult (RPKM 17.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A3.3; 13 14.05 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34363141..34530666, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34179158..34345275, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1605 Neighboring gene STARR-seq mESC enhancer starr_34140 Neighboring gene STARR-seq mESC enhancer starr_34143 Neighboring gene predicted gene, 36549 Neighboring gene STARR-seq mESC enhancer starr_34144 Neighboring gene proteasome (prosome, macropain) assembly chaperone 4 Neighboring gene STARR-seq mESC enhancer starr_34145 Neighboring gene STARR-seq mESC enhancer starr_34148 Neighboring gene VISTA enhancer mm1307 Neighboring gene predicted gene, 53791 Neighboring gene predicted gene 6129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. Christoforou N, et al. J Clin Invest, 2008 Mar. PMID 18246200, Free PMC Article
    2. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033167.3 → NP_001028339.1  solute carrier family 22 member 23 isoform 1

      See identical proteins and their annotated locations for NP_001028339.1

      Status: VALIDATED

      Source sequence(s)
      AC102087, AC129019, AC139242
      Consensus CDS
      CCDS26446.1
      UniProtKB/Swiss-Prot
      Q3UHH2, Q7TPT5
      UniProtKB/TrEMBL
      F7BP73
      Related
      ENSMUSP00000042742.6, ENSMUST00000040336.12
      Conserved Domains (2) summary
      cd06174
      Location:230 → 359
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:98 → 631
      2A0119; cation transport protein

    2. NM_001382849.1 → NP_001369778.1  solute carrier family 22 member 23 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102087, AC129019, AC139242
      UniProtKB/TrEMBL
      F7BP73
      Related
      ENSMUSP00000122283.2, ENSMUST00000148390.3
      Conserved Domains (1) summary
      cd17444
      Location:187 → 600
      MFS_SLC22A23; Solute carrier family 22, member 23 of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      34363141..34530666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247433.1 → XP_030103293.1  solute carrier family 22 member 23 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:134 → 485
      MFS; Major Facilitator Superfamily

    2. XM_030247434.2 → XP_030103294.1  solute carrier family 22 member 23 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:1 → 287
      MFS; Major Facilitator Superfamily

    3. XM_036158192.1 → XP_036014085.1  solute carrier family 22 member 23 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:187 → 359
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_004938073.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHH2.1 GenPept UniProtKB/Swiss-Prot:Q3UHH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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