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    Pnpo pyridoxine 5'-phosphate oxidase [ Mus musculus (house mouse) ]

    Gene ID: 103711, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pnpoprovided by MGI
    Official Full Name
    pyridoxine 5'-phosphate oxidaseprovided by MGI
    Primary source
    MGI:MGI:2144151
    See related
    Ensembl:ENSMUSG00000018659 AllianceGenome:MGI:2144151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable anion binding activity; protein homodimerization activity; and pyridoxamine-phosphate oxidase activity. Predicted to be involved in pyridoxal phosphate biosynthetic process. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14.5 (RPKM 227.8), liver E14 (RPKM 217.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 60.17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96828642..96834845, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96937816..96944019, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E202 Neighboring gene predicted gene 11525 Neighboring gene proline rich 15-like Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene RIKEN cDNA D030028A08 gene Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene Sp2 transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E11488 Neighboring gene STARR-positive B cell enhancer ABC_E20 Neighboring gene STARR-seq mESC enhancer starr_30576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vitamin B6 Addiction in Acute Myeloid Leukemia. Chen CC, et al. Cancer Cell, 2020 Jan 13. PMID 31935373, Free PMC Article
    2. Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase. Kang JH, et al. Eur J Biochem, 2004 Jun. PMID 15182361
    3. Absence of pyridoxine-5'-phosphate oxidase (PNPO) activity in neoplastic cells: isolation, characterization, and expression of PNPO cDNA. Ngo EO, et al. Biochemistry, 1998 May 26. PMID 9601034
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxamine phosphate oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pyridoxal phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pyridoxal phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyridoxal phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyridoxal phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyridoxamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyridoxine-5'-phosphate oxidase
    Names
    pyridoxamine-phosphate oxidase
    NP_598782.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134021.2 → NP_598782.1  pyridoxine-5'-phosphate oxidase

      See identical proteins and their annotated locations for NP_598782.1

      Status: VALIDATED

      Source sequence(s)
      AI464320, AK164667, AL596384, CK625276
      Consensus CDS
      CCDS25308.1
      UniProtKB/Swiss-Prot
      Q3TP70, Q3U445, Q3U4X1, Q91XF0
      Related
      ENSMUSP00000018803.6, ENSMUST00000018803.12
      Conserved Domains (3) summary
      TIGR00558
      Location:57 → 261
      pdxH; pyridoxamine-phosphate oxidase
      pfam01243
      Location:75 → 153
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      pfam10590
      Location:206 → 261
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96828642..96834845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XF0.1 GenPept UniProtKB/Swiss-Prot:Q91XF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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