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    Rsrc1 arginine/serine-rich coiled-coil 1 [ Mus musculus (house mouse) ]

    Gene ID: 66880, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Rsrc1provided by MGI
    Official Full Name
    arginine/serine-rich coiled-coil 1provided by MGI
    Primary source
    MGI:MGI:1914130
    See related
    Ensembl:ENSMUSG00000034544 AllianceGenome:MGI:1914130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SRrp53; 1200013F24Rik
    Summary
    Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; nucleocytoplasmic transport; and response to antibiotic. Located in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human RSRC1 (arginine and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 7.3), thymus adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rsrc1 in Genome Data Viewer
    Location:
    3 E1; 3 30.77 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (66888694..67265736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (66981364..67358403)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07879 Neighboring gene predicted gene, 54200 Neighboring gene STARR-seq mESC enhancer starr_07880 Neighboring gene STARR-seq mESC enhancer starr_07881 Neighboring gene STARR-seq mESC enhancer starr_07882 Neighboring gene Shox2 limb hindbrain control region Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07883 Neighboring gene SHOX homeobox 2 Neighboring gene predicted gene, 54201 Neighboring gene STARR-seq mESC enhancer starr_07884 Neighboring gene predicted gene, 22295 Neighboring gene STARR-positive B cell enhancer ABC_E6060 Neighboring gene STARR-positive B cell enhancer mm9_chr3:67177807-67178108 Neighboring gene myeloid leukemia factor 1 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene latexin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhancer redundancy provides phenotypic robustness in mammalian development. Osterwalder M, et al. Nature, 2018 Feb 8. PMID 29420474, Free PMC Article
    2. Shox2 function couples neural, muscular and skeletal development in the proximal forelimb. Vickerman L, et al. Dev Biol, 2011 Feb 15. PMID 21156168
    3. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Cazalla D, et al. Mol Cell Biol, 2005 Apr. PMID 15798186, Free PMC Article
    4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing.
      Title: A novel SR-related protein is required for the second step of Pre-mRNA splicing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103357

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/Arginine-related protein 53
    Names
    arginine/serine-rich coiled-coil protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356273.2 → NP_001343202.1  serine/Arginine-related protein 53 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q80XR9

    2. NM_001356274.2 → NP_001343203.1  serine/Arginine-related protein 53 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q80XR9

    3. NM_001356275.2 → NP_001343204.1  serine/Arginine-related protein 53 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      Consensus CDS
      CCDS89635.1
      UniProtKB/TrEMBL
      Q3TGY1, Q8CFJ0
      Related
      ENSMUSP00000047077.7, ENSMUST00000046542.13

    4. NM_001356277.2 → NP_001343206.1  serine/Arginine-related protein 53 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q8CFJ0

    5. NM_001356278.2 → NP_001343207.1  serine/Arginine-related protein 53 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      Consensus CDS
      CCDS89634.1
      UniProtKB/TrEMBL
      E9Q6P8, Q8CFJ0
      Related
      ENSMUSP00000125547.2, ENSMUST00000162693.8

    6. NM_001356279.2 → NP_001343208.1  serine/Arginine-related protein 53 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q8CFJ0

    7. NM_001356280.2 → NP_001343209.1  serine/Arginine-related protein 53 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q8BR75

    8. NM_025822.5 → NP_080098.1  serine/Arginine-related protein 53 isoform 2

      See identical proteins and their annotated locations for NP_080098.1

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      Consensus CDS
      CCDS17394.1
      UniProtKB/Swiss-Prot
      Q3TF06, Q9DBU6
      UniProtKB/TrEMBL
      Q80XR9
      Related
      ENSMUSP00000066797.8, ENSMUST00000065074.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      66888694..67265736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163232.1 → XP_036019125.1  serine/Arginine-related protein 53 isoform X5

    2. XM_017319694.3 → XP_017175183.1  serine/Arginine-related protein 53 isoform X1

      UniProtKB/TrEMBL
      Q9CSR8

    3. XM_036163231.1 → XP_036019124.1  serine/Arginine-related protein 53 isoform X3

    4. XM_017319692.3 → XP_017175181.1  serine/Arginine-related protein 53 isoform X1

      UniProtKB/TrEMBL
      Q9CSR8

    5. XM_006501911.5 → XP_006501974.1  serine/Arginine-related protein 53 isoform X4

    6. XM_006501913.5 → XP_006501976.1  serine/Arginine-related protein 53 isoform X5

    7. XM_011240198.3 → XP_011238500.2  serine/Arginine-related protein 53 isoform X2

      Conserved Domains (1) summary
      pfam18697
      Location:139 → 216
      MLVIN_C; Murine leukemia virus (MLV) integrase (IN) C-terminal domain

    8. XM_017319693.3 → XP_017175182.1  serine/Arginine-related protein 53 isoform X1

      UniProtKB/TrEMBL
      Q9CSR8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBU6.1 GenPept UniProtKB/Swiss-Prot:Q9DBU6

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