Tspan32 tetraspanin 32 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan32provided by MGI
Official Full Name: tetraspanin 32provided by MGI
Primary source: MGI:MGI:1350360
See related: Ensembl:ENSMUSG00000000244 AllianceGenome:MGI:1350360
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Art-1; Phemx; Tssc6; D7Wsu37e
Summary: Acts upstream of or within several processes, including defense response to protozoan; integrin-mediated signaling pathway; and negative regulation of myeloid dendritic cell activation. Located in cell surface. Part of integrin alphaIIb-beta3 complex. Is expressed in several structures, including central nervous system; ganglia; immune system; placenta; and tongue. Orthologous to human TSPAN32 (tetraspanin 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 20.5), liver E14.5 (RPKM 17.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.09 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142558644..142573223)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (143004907..143019486)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.
Title: TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.
Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability.
Title: A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets.
The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
Title: The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
absence of platelet TSSC6 affects the secondary stability of arterial thrombi in vivo upon vascular injury
Title: Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB207104 (e-PCR)
- UniSTS:208230

Phemx (e-PCR), detects polymorphism
- UniSTS:142707

RH124603 (e-PCR)
- UniSTS:161425

BB235973 (e-PCR)
- UniSTS:185746

AW208513 (e-PCR)
- UniSTS:179679

Tspan32 (e-PCR), detects polymorphism
- UniSTS:465403

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of defense response to virus	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphaIIb-beta3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetraspanin-32

Names: AML1-regulated transmembrane protein 1; pan hematopoietic expression; protein Phemx; tspan-32; tumor-suppressing subchromosomal transferable fragment 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128080.2 → NP_001121552.1 tetraspanin-32 isoform a

See identical proteins and their annotated locations for NP_001121552.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AY039000

Consensus CDS

CCDS52459.1

UniProtKB/Swiss-Prot

Q923G9, Q9ESH0, Q9JHH2, Q9JHQ9, Q9JHR0, Q9JHR1, Q9JHR2, Q9JHS8

Related

ENSMUSP00000009396.7, ENSMUST00000009396.13

Conserved Domains (2) summary

cd03153
Location:113 → 228

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:11 → 223

Tetraspannin; Tetraspanin family
NM_001128081.1 → NP_001121553.1 tetraspanin-32 isoform c

See identical proteins and their annotated locations for NP_001121553.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.

Source sequence(s)

AJ279792, BY208601

Consensus CDS

CCDS52460.1

UniProtKB/TrEMBL

Q7TNQ7

Related

ENSMUSP00000080668.6, ENSMUST00000082008.12

Conserved Domains (1) summary

cd03153
Location:86 → 173

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
NM_001128082.1 → NP_001121554.1 tetraspanin-32 isoform d

See identical proteins and their annotated locations for NP_001121554.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks two alternate internal segment compared to isoform a.

Source sequence(s)

AJ279794, BY208601

Consensus CDS

CCDS52461.1

UniProtKB/TrEMBL

G3X9S3

Related

ENSMUSP00000101543.2, ENSMUST00000105923.8

Conserved Domains (1) summary

cl02781
Location:47 → 139

tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
NM_020286.3 → NP_064682.1 tetraspanin-32 isoform b

See identical proteins and their annotated locations for NP_064682.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AF291425, BY208601

Consensus CDS

CCDS22037.1

UniProtKB/TrEMBL

D3Z0S2, Q3U3L6

Related

ENSMUSP00000074667.6, ENSMUST00000075172.12

Conserved Domains (1) summary

cd03153
Location:86 → 201

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

142558644..142573223

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508624.4 → XP_006508687.1 tetraspanin-32 isoform X6

Conserved Domains (2) summary

cd03153
Location:128 → 191

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:11 → 171

Tetraspannin; Tetraspanin family
XM_006508620.4 → XP_006508683.1 tetraspanin-32 isoform X2

Conserved Domains (2) summary

cd03153
Location:128 → 210

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:11 → 171

Tetraspannin; Tetraspanin family
XM_006508625.4 → XP_006508688.1 tetraspanin-32 isoform X7

Conserved Domains (1) summary

cd03153
Location:74 → 166

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
XM_006508619.4 → XP_006508682.1 tetraspanin-32 isoform X1

Conserved Domains (2) summary

cd03153
Location:128 → 238

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:11 → 171

Tetraspannin; Tetraspanin family
XM_006508622.4 → XP_006508685.1 tetraspanin-32 isoform X4

Conserved Domains (2) summary

cd03153
Location:113 → 200

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:11 → 161

Tetraspannin; Tetraspanin family
XM_006508623.4 → XP_006508686.1 tetraspanin-32 isoform X5

Conserved Domains (1) summary

cl02781
Location:74 → 194

tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
XM_006508621.4 → XP_006508684.1 tetraspanin-32 isoform X3

UniProtKB/TrEMBL

D3Z0S2

Related

ENSMUSP00000115344.2, ENSMUST00000143512.3

Conserved Domains (1) summary

cd03153
Location:94 → 203

PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...