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    Fsd1 fibronectin type 3 and SPRY domain-containing protein [ Mus musculus (house mouse) ]

    Gene ID: 240121, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fsd1provided by MGI
    Official Full Name
    fibronectin type 3 and SPRY domain-containing proteinprovided by MGI
    Primary source
    MGI:MGI:1934858
    See related
    Ensembl:ENSMUSG00000011589 AllianceGenome:MGI:1934858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in cytoplasmic microtubule organization; regulation of cytokinesis; and regulation of mitotic spindle organization. Predicted to act upstream of or within cell division. Predicted to be located in centrosome and microtubule. Is expressed in nervous system and sensory organ. Orthologous to human FSD1 (fibronectin type III and SPRY domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 45.8), whole brain E14.5 (RPKM 38.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fsd1 in Genome Data Viewer
    Location:
    17 D; 17 29.1 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56293475..56303881)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55986462..55996883)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16712 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene signal transducing adaptor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2497 Neighboring gene MPN domain containing Neighboring gene bolA-like 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension. Baneyx G, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11959962, Free PMC Article
    2. Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. Carim-Todd L, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267680
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension
      Title: Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC58341

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III and SPRY domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411202.1 → NP_001398131.1  fibronectin type III and SPRY domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009719

    2. NM_001411203.1 → NP_001398132.1  fibronectin type III and SPRY domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT009719

    3. NM_001411204.1 → NP_001398133.1  fibronectin type III and SPRY domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009719

    4. NM_001411205.1 → NP_001398134.1  fibronectin type III and SPRY domain-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT009719

    5. NM_001411206.1 → NP_001398135.1  fibronectin type III and SPRY domain-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT009719

    6. NM_001411207.1 → NP_001398136.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009719

    7. NM_001411208.1 → NP_001398137.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009719

    8. NM_001411209.1 → NP_001398138.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009719

    9. NM_183178.3 → NP_899001.1  fibronectin type III and SPRY domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_899001.1

      Status: VALIDATED

      Source sequence(s)
      CT009719
      Consensus CDS
      CCDS37661.1
      UniProtKB/Swiss-Prot
      Q3UNE6, Q7TPM6
      Related
      ENSMUSP00000011733.9, ENSMUST00000011733.9
      Conserved Domains (3) summary
      cd00063
      Location:165 → 265
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:270 → 476
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
      cl23765
      Location:4 → 120
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RNA

    1. NR_177196.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009719

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56293475..56303881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPM6.1 GenPept UniProtKB/Swiss-Prot:Q7TPM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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