Dnajb3 DnaJ heat shock protein family (Hsp40) member B3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajb3provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member B3provided by MGI
Primary source: MGI:MGI:1306822
See related: Ensembl:ENSMUSG00000081984 AllianceGenome:MGI:1306822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hsj3; Msj1; MSJ-1
Summary: Predicted to enable chaperone binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein folding. Located in acrosomal vesicle and centrosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human DNAJB3 (DnaJ heat shock protein family (Hsp40) member B3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 1 D; 1 44.55 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (88132454..88133470, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (88204732..88205748, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes.
Title: Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes.
msj-1 gene might be conserved among vertebrates and might exert fundamental functions in reproduction.
Title: Structure of msj-1 gene in mice and humans: a possible role in the regulation of male reproduction.
Analysis of msj-1 genomic sequence reveals that msj-1 is an intronless gene.
Title: Structure of msj-1 gene: a comparative analysis.
a molecular chaperone, specifically expressed in testis, associates with the acrosome and centrosome in mouse germ cells
Title: mUBPy and MSJ-1, a deubiquitinating enzyme and a molecular chaperone specifically expressed in testis, associate with the acrosome and centrosome in mouse germ cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dnaJ homolog subfamily B member 3

Names: DnaJ (Hsp40) homolog, subfamily B, member 3; HSJ-3; dnaJ protein homolog 3; heat shock protein J3; heat shock protein, DNAJ-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.