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    Fbrsl1 fibrosin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 381668, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fbrsl1provided by MGI
    Official Full Name
    fibrosin-like 1provided by MGI
    Primary source
    MGI:MGI:1920907
    See related
    Ensembl:ENSMUSG00000043323 AllianceGenome:MGI:1920907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1049; Gm29766; mKIAA1545; 2410025L10Rik
    Summary
    Is expressed in testis. Orthologous to human FBRSL1 (fibrosin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 37.3), ovary adult (RPKM 25.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbrsl1 in Genome Data Viewer
    Location:
    5 F; 5 53.51 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110509617..110596369, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110361751..110448503, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 2 Neighboring gene leucine rich colipase-like 1 Neighboring gene STARR-seq mESC enhancer starr_13955 Neighboring gene STARR-positive B cell enhancer ABC_E3598 Neighboring gene STARR-seq mESC enhancer starr_13957 Neighboring gene predicted gene, 32996 Neighboring gene RIKEN cDNA A630023P12 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    fibrosin-1-like protein
    Names
    AUTS2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142642.1 → NP_001136114.1  fibrosin-1-like protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AW492835, BC059932, BP764457, BU614458, BY733978, CA321720, CX204847
      Consensus CDS
      CCDS51609.1
      UniProtKB/TrEMBL
      A0A0G2JDI2, E9Q9T0
      Related
      ENSMUSP00000063879.6, ENSMUST00000069483.12
      Conserved Domains (1) summary
      pfam15336
      Location:564 → 767
      Auts2; Autism susceptibility gene 2 protein

    2. NM_001317042.1 → NP_001303971.1  fibrosin-1-like protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC169384
      UniProtKB/TrEMBL
      A0A571BFB2
      Conserved Domains (1) summary
      PHA03247
      Location:395 → 547
      PHA03247; large tegument protein UL36; Provisional

    3. NM_028596.2 → NP_082872.2  fibrosin-1-like protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate promoter and lacks an in-frame portion of the 5' coding region, compared to variant 1. It also lacks two alternate in-frame exons on the central coding region. The resulting isoform (2) has a shorter N-terminus and lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AK031967, AW492835, BC059932, BP764457, CA321720, CJ057461
      Consensus CDS
      CCDS39211.1
      UniProtKB/TrEMBL
      A0A0G2JFF2, E9PUB6
      Related
      ENSMUSP00000054613.7, ENSMUST00000056124.11
      Conserved Domains (1) summary
      pfam15336
      Location:150 → 329
      Auts2; Autism susceptibility gene 2 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110509617..110596369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_105032.1: Suppressed sequence

      Description
      NR_105032.1: This RefSeq was removed because the gene was discontinued.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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