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    Eno4 enolase 4 [ Mus musculus (house mouse) ]

    Gene ID: 226265, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Eno4provided by MGI
    Official Full Name
    enolase 4provided by MGI
    Primary source
    MGI:MGI:2441717
    See related
    Ensembl:ENSMUSG00000048029 AllianceGenome:MGI:2441717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430537H07Rik
    Summary
    Enables phosphopyruvate hydratase activity. Acts upstream of or within cilium organization; flagellated sperm motility; and glycolytic process. Located in sperm principal piece. Is expressed in choroid invagination; embryo; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Orthologous to human ENO4 (enolase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 4.2), lung adult (RPKM 0.5) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 D2; 19 54.55 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (58922490..58959853)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (58934058..58971421)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 12A Neighboring gene predicted gene, 52393 Neighboring gene STARR-seq mESC enhancer starr_46588 Neighboring gene microRNA 3086 Neighboring gene STARR-seq mESC enhancer starr_46589 Neighboring gene shootin 1 Neighboring gene predicted gene, 57667

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Nakamura N, et al. Biol Reprod, 2013 Apr. PMID 23446454, Free PMC Article
    2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ENO4 is required for normal assembly of the fibrous sheath and provides most of the enolase activity in sperm.
      Title: Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Homology

    Clone Names

    • MGC30738

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopyruvate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enolase 4
    Names
    2-phospho-D-glycerate hydro-lyase
    enolase-like protein C10orf134 homolog
    enolase-like protein ENO4
    NP_848804.2
    XP_006527117.1
    XP_006527118.1
    XP_006527119.1
    XP_030106782.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178689.5 → NP_848804.2  enolase 4

      Status: VALIDATED

      Source sequence(s)
      AC102604
      Consensus CDS
      CCDS79725.1
      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      UniProtKB/TrEMBL
      A0A0J9YUP0
      Related
      ENSMUSP00000144272.2, ENSMUST00000200910.4
      Conserved Domains (2) summary
      TIGR01060
      Location:68 → 570
      eno; phosphopyruvate hydratase
      cl21457
      Location:236 → 569
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      58922490..58959853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527054.4 → XP_006527117.1  enolase 4 isoform X1

      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      Conserved Domains (1) summary
      TIGR01060
      Location:68 → 570
      eno; phosphopyruvate hydratase

    2. XM_006527055.4 → XP_006527118.1  enolase 4 isoform X2

      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      Conserved Domains (1) summary
      TIGR01060
      Location:68 → 507
      eno; phosphopyruvate hydratase

    3. XM_006527056.4 → XP_006527119.1  enolase 4 isoform X3

      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      Conserved Domains (1) summary
      TIGR01060
      Location:68 → 507
      eno; phosphopyruvate hydratase

    4. XM_030250922.1 → XP_030106782.1  enolase 4 isoform X4

      UniProtKB/TrEMBL
      A0A0J9YVG9
      Related
      ENSMUSP00000144656.2, ENSMUST00000202382.4
      Conserved Domains (1) summary
      TIGR01060
      Location:2 → 333
      eno; phosphopyruvate hydratase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C042.2 GenPept UniProtKB/Swiss-Prot:Q8C042

    Gene LinkOut

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