Polr3k polymerase (RNA) III (DNA directed) polypeptide K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Polr3kprovided by MGI
Official Full Name: polymerase (RNA) III (DNA directed) polypeptide Kprovided by MGI
Primary source: MGI:MGI:1914255
See related: Ensembl:ENSMUSG00000038628 AllianceGenome:MGI:1914255
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C11; RPC10; RPC11; 12.3kDa; 1500004O14Rik
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in termination of RNA polymerase III transcription. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including 1st branchial arch; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 15.7), whole brain E14.5 (RPKM 15.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.82 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (181506153..181512623)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (181864360..181870830)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI196849 (e-PCR)
- UniSTS:178799

AU014893 (e-PCR)
- UniSTS:208803

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase III transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit RPC10

Names: DNA-directed RNA polymerase III subunit K; RNA polymerase III subunit C10; RNA polymerase III subunit C11

NP_080177.1

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025901.3 → NP_080177.1 DNA-directed RNA polymerase III subunit RPC10

See identical proteins and their annotated locations for NP_080177.1

Status: VALIDATED

Source sequence(s)

AK031110, AK161764, BY003788

Consensus CDS

CCDS17225.1

UniProtKB/Swiss-Prot

Q9CQZ7, Q9D1U1

UniProtKB/TrEMBL

Q8BU05

Related

ENSMUSP00000044582.9, ENSMUST00000039551.9

Conserved Domains (2) summary

COG1594
Location:1 → 108

RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]

cd10509
Location:61 → 108

Zn-ribbon_RPC11; C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III