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    Neu2 neuraminidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23956, updated on 23-Jun-2021

    Summary

    Official Symbol
    Neu2provided by MGI
    Official Full Name
    neuraminidase 2provided by MGI
    Primary source
    MGI:MGI:1344417
    See related
    Ensembl:ENSMUSG00000079434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M; MB; MT; MBS; MSS; MTS
    Expression
    Biased expression in mammary gland adult (RPKM 11.9), kidney adult (RPKM 6.1) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Neu2 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87501749..87525567)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87574027..87597845)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89470602..89494420)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene predicted gene 6153 Neighboring gene predicted gene, 46099 Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene predicted gene, 33470 Neighboring gene predicted gene, 33517

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables exo-alpha-(2->3)-sialidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables exo-alpha-(2->3)-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables exo-alpha-(2->6)-sialidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exo-alpha-(2->8)-sialidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables exo-alpha-(2->8)-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables exo-alpha-sialidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables exo-alpha-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sialidase-2
    Names
    N-acetyl-alpha-neuraminidase 2
    brain sialidase
    cystolic sialidase
    cytosolic sialidase
    murine thymic sialidase
    skeletal muscle sialidase
    NP_001153635.1
    NP_001153636.1
    NP_001153637.1
    NP_056565.1
    XP_006529587.1
    XP_036020549.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160163.1NP_001153635.1  sialidase-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB028023, AC102564, AK145284, FJ613504
      Consensus CDS
      CCDS48308.1
      UniProtKB/Swiss-Prot
      Q9JMH3
      UniProtKB/TrEMBL
      C0KJU9, E9Q0I0, Q3ULV6
      Related
      ENSMUSP00000131409.2, ENSMUST00000172222.8
      Conserved Domains (2) summary
      cd15482
      Location:24381
      Sialidase_non-viral; Non-viral sialidases
      pfam13088
      Location:46359
      BNR_2; BNR repeat-like domain
    2. NM_001160164.1NP_001153636.1  sialidase-2 isoform 2

      See identical proteins and their annotated locations for NP_001153636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AB048604, AC102564, AK145284
      Consensus CDS
      CCDS15135.1
      UniProtKB/Swiss-Prot
      Q9JMH3
      UniProtKB/TrEMBL
      Q0VGI4, Q3ULV6
      Related
      ENSMUSP00000132513.2, ENSMUST00000166259.8
      Conserved Domains (1) summary
      cd15482
      Location:10367
      Sialidase_non-viral; Non-viral sialidases
    3. NM_001160165.1NP_001153637.1  sialidase-2 isoform 3

      See identical proteins and their annotated locations for NP_001153637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform 3) contains a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB048604, AC102564, BY088515
      Consensus CDS
      CCDS48309.1
      UniProtKB/Swiss-Prot
      Q9JMH3
      UniProtKB/TrEMBL
      A0A0R4J224
      Related
      ENSMUSP00000127913.2, ENSMUST00000164128.2
      Conserved Domains (2) summary
      cd15482
      Location:16373
      Sialidase_non-viral; Non-viral sialidases
      pfam13088
      Location:38351
      BNR_2; BNR repeat-like domain
    4. NM_015750.3NP_056565.1  sialidase-2 isoform 4

      See identical proteins and their annotated locations for NP_056565.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform 4) contains a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB028023, AC102564
      Consensus CDS
      CCDS15135.1
      UniProtKB/Swiss-Prot
      Q9JMH3
      UniProtKB/TrEMBL
      Q0VGI4
      Related
      ENSMUSP00000065439.6, ENSMUST00000070898.6
      Conserved Domains (1) summary
      cd15482
      Location:10367
      Sialidase_non-viral; Non-viral sialidases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      87501749..87525567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164656.1XP_036020549.1  sialidase-2 isoform X1

      Conserved Domains (1) summary
      cd15482
      Location:10367
      Sialidase_non-viral; Non-viral sialidases
    2. XM_006529524.5XP_006529587.1  sialidase-2 isoform X1

      See identical proteins and their annotated locations for XP_006529587.1

      UniProtKB/Swiss-Prot
      Q9JMH3
      UniProtKB/TrEMBL
      Q0VGI4
      Conserved Domains (1) summary
      cd15482
      Location:10367
      Sialidase_non-viral; Non-viral sialidases
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