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    Rab36 RAB36, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 76877, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab36provided by MGI
    Official Full Name
    RAB36, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1924127
    See related
    Ensembl:ENSMUSG00000020175 AllianceGenome:MGI:1924127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330593L16Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to act upstream of or within protein transport. Predicted to be located in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human RAB36 (RAB36, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 8.5), ovary adult (RPKM 7.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 38.49 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (74872727..74890580)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75036895..75054748)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene radial spoke head homolog 14 (Chlamydomonas) Neighboring gene guanine nucleotide binding protein, alpha z subunit Neighboring gene predicted gene, 40692 Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene STARR-positive B cell enhancer ABC_E10622 Neighboring gene STARR-positive B cell enhancer mm9_chr10:74614065-74614365 Neighboring gene STARR-seq mESC enhancer starr_27150 Neighboring gene STARR-positive B cell enhancer ABC_E2943 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like Neighboring gene STARR-seq mESC enhancer starr_27151 Neighboring gene predicted gene, 46234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes. Matsui T, et al. J Biol Chem, 2012 Aug 17. PMID 22740695, Free PMC Article
    2. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
    3. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
    4. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12578829
    5. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab36 mediates retrograde melanosome transport in melanocytes through interaction with RILP.
      Title: The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-36
    NP_001346199.1
    NP_001346200.1
    NP_001346201.1
    XP_006514350.1
    XP_006514352.1
    XP_006514353.1
    XP_006514355.1
    XP_006514356.1
    XP_006514357.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359270.1 → NP_001346199.1  ras-related protein Rab-36

      Status: VALIDATED

      Source sequence(s)
      AK038445, BQ173929, BY281467
      Consensus CDS
      CCDS23923.2
      UniProtKB/Swiss-Prot
      Q8CAM5
      UniProtKB/TrEMBL
      Q3V389
      Related
      ENSMUSP00000119399.2, ENSMUST00000147802.9
      Conserved Domains (1) summary
      cl38936
      Location:58 → 223
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001359271.1 → NP_001346200.1  ras-related protein Rab-36

      Status: VALIDATED

      Source sequence(s)
      AK046113, BQ173929, BY281467, CJ315423
      Consensus CDS
      CCDS23923.2
      UniProtKB/Swiss-Prot
      Q8CAM5
      UniProtKB/TrEMBL
      Q3V389
      Conserved Domains (1) summary
      cl38936
      Location:58 → 223
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001359272.1 → NP_001346201.1  ras-related protein Rab-36

      Status: VALIDATED

      Source sequence(s)
      AC142500, AK038445, AK142415, BQ173929, CJ315423
      Consensus CDS
      CCDS23923.2
      UniProtKB/Swiss-Prot
      Q8CAM5
      UniProtKB/TrEMBL
      Q3V389
      Related
      ENSMUSP00000121693.2, ENSMUST00000146440.3
      Conserved Domains (1) summary
      cl38936
      Location:58 → 223
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      74872727..74890580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514289.1 → XP_006514352.1  ras-related protein Rab-36 isoform X1

      See identical proteins and their annotated locations for XP_006514352.1

      UniProtKB/Swiss-Prot
      Q8CAM5
      UniProtKB/TrEMBL
      Q3V389
      Conserved Domains (1) summary
      cl38936
      Location:58 → 223
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006514287.1 → XP_006514350.1  ras-related protein Rab-36 isoform X1

      See identical proteins and their annotated locations for XP_006514350.1

      UniProtKB/Swiss-Prot
      Q8CAM5
      UniProtKB/TrEMBL
      Q3V389
      Conserved Domains (1) summary
      cl38936
      Location:58 → 223
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_006514290.1 → XP_006514353.1  ras-related protein Rab-36 isoform X1

      See identical proteins and their annotated locations for XP_006514353.1

      UniProtKB/Swiss-Prot
      Q8CAM5
      UniProtKB/TrEMBL
      Q3V389
      Conserved Domains (1) summary
      cl38936
      Location:58 → 223
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_006514293.1 → XP_006514356.1  ras-related protein Rab-36 isoform X2

      See identical proteins and their annotated locations for XP_006514356.1

      Conserved Domains (1) summary
      cl38936
      Location:58 → 132
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_006514294.4 → XP_006514357.1  ras-related protein Rab-36 isoform X2

      See identical proteins and their annotated locations for XP_006514357.1

      Conserved Domains (1) summary
      cl38936
      Location:58 → 132
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_006514292.3 → XP_006514355.1  ras-related protein Rab-36 isoform X2

      See identical proteins and their annotated locations for XP_006514355.1

      Conserved Domains (1) summary
      cl38936
      Location:58 → 132
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_380455.1 RNA Sequence

    2. XR_004936302.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029781.3: Suppressed sequence

      Description
      NM_029781.3: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CAM5.1 GenPept UniProtKB/Swiss-Prot:Q8CAM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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