Ogg1 8-oxoguanine DNA-glycosylase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ogg1provided by MGI
Official Full Name: 8-oxoguanine DNA-glycosylase 1provided by MGI
Primary source: MGI:MGI:1097693
See related: Ensembl:ENSMUSG00000030271 AllianceGenome:MGI:1097693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mmh
Summary: Enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity and microtubule binding activity. Acts upstream of or within base-excision repair. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 11.9), ovary adult (RPKM 9.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113303959..113311149)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113326972..113334877)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Catalytic activity of OGG1 is impaired by Zinc deficiency.
Title: Catalytic activity of OGG1 is impaired by Zinc deficiency.
OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.
Title: OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.
8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-kappaB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276.
Title: 8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-κB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276.
Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1.
Title: Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1.
Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.
Title: Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.
8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury.
Title: 8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury.
Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases.
Title: Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases.
DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development.
Title: DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development.
OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culturedagger.
Title: OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†.
MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
Title: MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Ertd263e (e-PCR), detects polymorphism
- UniSTS:167474

AI505105 (e-PCR)
- UniSTS:159558

Ogg1 (e-PCR), detects polymorphism
- UniSTS:144081

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	ISO Inferred from Sequence Orthology more info
enables DNA N-glycosylase activity	ISO Inferred from Sequence Orthology more info
enables DNA N-glycosylase activity	TAS Traceable Author Statement more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidized base lesion DNA N-glycosylase activity	TAS Traceable Author Statement more info	PubMed
enables oxidized purine DNA binding	ISO Inferred from Sequence Orthology more info
enables oxidized purine nucleobase lesion DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidized purine nucleobase lesion DNA N-glycosylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidized purine nucleobase lesion DNA N-glycosylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within DNA repair	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within base-excision repair	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair, AP site formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of double-strand break repair via single-strand annealing	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within nucleotide-excision repair	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to radiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: N-glycosylase/DNA lyase

NP_001397059.1

EC 4.2.99.18

NP_001397060.1

EC 4.2.99.18

NP_001397061.1

EC 4.2.99.18

NP_035087.3

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410130.1 → NP_001397059.1 N-glycosylase/DNA lyase isoform 3

Status: VALIDATED

Source sequence(s)

AC155287
NM_001410131.1 → NP_001397060.1 N-glycosylase/DNA lyase isoform 4

Status: VALIDATED

Source sequence(s)

AC155287
NM_001410132.1 → NP_001397061.1 N-glycosylase/DNA lyase isoform 5

Status: VALIDATED

Source sequence(s)

AC155287
NM_010957.5 → NP_035087.3 N-glycosylase/DNA lyase isoform 1

See identical proteins and their annotated locations for NP_035087.3

Status: VALIDATED

Source sequence(s)

AC155287

Consensus CDS

CCDS20414.1

UniProtKB/Swiss-Prot

O08733, O08760, O08910, O08991, O35617, O35915, Q9QXE8

UniProtKB/TrEMBL

Q3UIL3

Related

ENSMUSP00000032406.9, ENSMUST00000032406.15

Conserved Domains (3) summary

TIGR00588
Location:11 → 328

ogg; 8-oxoguanine DNA-glycosylase (ogg)

cd00056
Location:139 → 319

ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases

pfam07934
Location:25 → 141

OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

RNA

NR_149720.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC155287

Related

ENSMUST00000136263.4
NR_176953.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC155287

Related

ENSMUST00000204834.3