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    Gatb glutamyl-tRNA amidotransferase subunit B [ Mus musculus (house mouse) ]

    Gene ID: 229487, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gatbprovided by MGI
    Official Full Name
    glutamyl-tRNA amidotransferase subunit Bprovided by MGI
    Primary source
    MGI:MGI:2442496
    See related
    Ensembl:ENSMUSG00000028085 AllianceGenome:MGI:2442496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pet112; Pet112l; 9430026F02Rik
    Summary
    Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to human GATB (glutamyl-tRNA amidotransferase subunit B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 8.6), heart adult (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gatb in Genome Data Viewer
    Location:
    3 F1; 3 37.83 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (85481409..85562945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (85574102..85655624)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31419 Neighboring gene microRNA 466k Neighboring gene STARR-seq mESC enhancer starr_08109 Neighboring gene predicted gene 3740 Neighboring gene STARR-positive B cell enhancer ABC_E6064 Neighboring gene predicted gene, 54168 Neighboring gene predicted gene, 46809 Neighboring gene STARR-seq mESC enhancer starr_08111 Neighboring gene FHF complex subunit HOOK interacting protein 1A Neighboring gene predicted gene, 40082 Neighboring gene STARR-seq mESC enhancer starr_08112 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo. Echevarría L, et al. Biochem J, 2014 May 15. PMID 24579914
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11629

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glutamyl-tRNA(Gln) amidotransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
    Names
    PET112 homolog
    cytochrome c oxidase assembly factor PET112 homolog
    cytochrome oxidase assembly factor PET112 homolog
    glu-AdT subunit B
    glutamyl-tRNA(Gln) amidotransferase, subunit B
    probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
    NP_001386159.1
    NP_659145.1
    XP_006501392.1
    XP_006501393.1
    XP_006501394.1
    XP_011238382.1
    XP_036018934.1
    XP_036018935.1
    XP_036018936.1
    XP_036018937.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399230.1 → NP_001386159.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102296, AC102338
      UniProtKB/TrEMBL
      Q8BW84
      Related
      ENSMUSP00000103301.2, ENSMUST00000107674.2
      Conserved Domains (1) summary
      PRK05477
      Location:62 → 516
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    2. NM_144896.5 → NP_659145.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_659145.1

      Status: VALIDATED

      Source sequence(s)
      AC102296, AC102338
      Consensus CDS
      CCDS17441.1
      UniProtKB/Swiss-Prot
      Q8BMU3, Q8BUY3, Q99JT1
      UniProtKB/TrEMBL
      Q3TLZ6
      Related
      ENSMUSP00000119949.2, ENSMUST00000127348.8
      Conserved Domains (3) summary
      PRK05477
      Location:62 → 555
      gatB; aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated
      pfam02637
      Location:406 → 555
      GatB_Yqey; GatB domain
      pfam02934
      Location:65 → 351
      GatB_N; GatB/GatE catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      85481409..85562945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501329.3 → XP_006501392.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK05477
      Location:62 → 580
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    2. XM_006501330.2 → XP_006501393.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK05477
      Location:62 → 620
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    3. XM_036163041.1 → XP_036018934.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X3

      UniProtKB/TrEMBL
      Q3TLZ6
      Conserved Domains (1) summary
      PRK05477
      Location:62 → 575
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    4. XM_006501331.3 → XP_006501394.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X4

      UniProtKB/TrEMBL
      Q3TLZ6
      Conserved Domains (1) summary
      PRK05477
      Location:62 → 515
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    5. XM_036163042.1 → XP_036018935.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X5

      UniProtKB/TrEMBL
      Q3TLZ6
      Conserved Domains (1) summary
      PRK05477
      Location:62 → 510
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    6. XM_036163044.1 → XP_036018937.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X8

      Conserved Domains (1) summary
      PRK05477
      Location:54 → 458
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    7. XM_036163043.1 → XP_036018936.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X7

      Conserved Domains (1) summary
      PRK05477
      Location:54 → 503
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    8. XM_011240080.3 → XP_011238382.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X6

      Conserved Domains (1) summary
      PRK05477
      Location:54 → 463
      gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

    RNA

    1. XR_375512.3 RNA Sequence

    2. XR_004941305.1 RNA Sequence

    3. XR_003954307.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JT1.1 GenPept UniProtKB/Swiss-Prot:Q99JT1

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