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    Adam32 a disintegrin and metallopeptidase domain 32 [ Mus musculus (house mouse) ]

    Gene ID: 353188, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Adam32provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 32provided by MGI
    Primary source
    MGI:MGI:2653822
    See related
    Ensembl:ENSMUSG00000037437 AllianceGenome:MGI:2653822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
    Expression
    Restricted expression toward testis adult (RPKM 110.6) See more
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    Genomic context

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    Location:
    8 A2; 8 13.65 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25326159..25438933, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24836143..24948918, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51566 Neighboring gene predicted gene, 26208 Neighboring gene ADAM metallopeptidase domain 3 Neighboring gene STARR-seq mESC enhancer starr_20948 Neighboring gene a disintegrin and metallopeptidase domain 5 Neighboring gene STARR-seq mESC enhancer starr_20951 Neighboring gene STARR-seq mESC enhancer starr_20952 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene STARR-positive B cell enhancer mm9_chr8:26127373-26127674 Neighboring gene TM2 domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normal fertility in male mice lacking ADAM32 with testis-specific expression. Lee S, et al. Reprod Biol, 2020 Dec. PMID 32972883
    2. Identification and characterization of ADAM32 with testis-predominant gene expression. Choi I, et al. Gene, 2003 Jan 30. PMID 12568724
    3. Expression and relationship of male reproductive ADAMs in mouse. Kim T, et al. Biol Reprod, 2006 Apr. PMID 16407499
    4. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Normal fertility in male mice lacking ADAM32 with testis-specific expression.
      Title: Normal fertility in male mice lacking ADAM32 with testis-specific expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 32
    Names
    a disintegrin and metalloprotease domain 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293693.2 → NP_001280622.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001280622.1

      Status: VALIDATED

      Source sequence(s)
      AC117643, AC156553
      Consensus CDS
      CCDS80867.1
      UniProtKB/Swiss-Prot
      Q8K410
      Related
      ENSMUSP00000113076.2, ENSMUST00000119720.8
      Conserved Domains (5) summary
      smart00608
      Location:483 → 622
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:188 → 382
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:400 → 479
      Disintegrin; Disintegrin
      pfam01421
      Location:188 → 384
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40 → 144
      Pep_M12B_propep; Reprolysin family propeptide

    2. NM_001426375.1 → NP_001413304.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117643, AC156553

    3. NM_153397.3 → NP_700446.2  disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_700446.2

      Status: VALIDATED

      Source sequence(s)
      AC117643, AC156553
      Consensus CDS
      CCDS40300.2
      UniProtKB/Swiss-Prot
      Q6P901, Q8BJ80, Q8K410
      Related
      ENSMUSP00000113627.3, ENSMUST00000121438.9
      Conserved Domains (5) summary
      smart00608
      Location:483 → 622
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:188 → 382
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:400 → 479
      Disintegrin; Disintegrin
      pfam01421
      Location:188 → 384
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40 → 144
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25326159..25438933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509162.3 → XP_006509225.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

      Conserved Domains (4) summary
      smart00608
      Location:483 → 622
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:400 → 478
      Disintegrin
      pfam01421
      Location:188 → 384
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:33 → 145
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. XR_378789.2 RNA Sequence

    2. XR_378788.2 RNA Sequence

    3. XR_004934847.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K410.3 GenPept UniProtKB/Swiss-Prot:Q8K410

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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