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    Pecr peroxisomal trans-2-enoyl-CoA reductase [ Mus musculus (house mouse) ]

    Gene ID: 111175, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pecrprovided by MGI
    Official Full Name
    peroxisomal trans-2-enoyl-CoA reductaseprovided by MGI
    Primary source
    MGI:MGI:2148199
    See related
    Ensembl:ENSMUSG00000026189 AllianceGenome:MGI:2148199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TERP; 2400003B18Rik
    Summary
    Predicted to enable signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in phytol metabolic process. Predicted to act upstream of or within fatty acid elongation. Located in mitochondrion. Is expressed in alimentary system; gland; liver; and pancreas. Orthologous to human PECR (peroxisomal trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 84.9), kidney adult (RPKM 79.9) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C3; 1 36.46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72298331..72323480, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72259172..72284321, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D230017M19 gene Neighboring gene STARR-seq mESC enhancer starr_01271 Neighboring gene STARR-positive B cell enhancer ABC_E5771 Neighboring gene predicted gene, 24497 Neighboring gene predicted gene, 25939 Neighboring gene transmembrane protein 169 Neighboring gene predicted gene, 51631 Neighboring gene STARR-positive B cell enhancer ABC_E4322 Neighboring gene STARR-seq mESC enhancer starr_01273 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 5 Neighboring gene STARR-seq mESC enhancer starr_01274

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. Luo Q, et al. Acta Histochem, 2023 Feb. PMID 36724637
    2. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. Das AK, et al. J Biol Chem, 2000 Aug 11. PMID 10811639
    3. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. Amery L, et al. Comb Chem High Throughput Screen, 2001 Nov. PMID 11669066
    4. Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Cossette SM, et al. Biol Open, 2014 Dec 12. PMID 25505152, Free PMC Article
    5. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells.
      Title: Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells.
    2. a paper describing the functions of peroxisomal trans 2-enoyl CoA reductase
      Title: Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid elongation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phytol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phytol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal trans-2-enoyl-CoA reductase
    Names
    perosisomal 2-enoyl-CoA reductase
    NP_001343445.1
    NP_076012.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356516.1 → NP_001343445.1  peroxisomal trans-2-enoyl-CoA reductase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in its' 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC114905, AC120136
      Conserved Domains (1) summary
      cl25409
      Location:2 → 121
      SDR; Short-chain dehydrogenases/reductases (SDR)

    2. NM_023523.6 → NP_076012.3  peroxisomal trans-2-enoyl-CoA reductase isoform 1

      See identical proteins and their annotated locations for NP_076012.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK010260, AK162100, BY286611, CB723327
      Consensus CDS
      CCDS35607.1
      UniProtKB/Swiss-Prot
      Q99MZ7, Q9CX01, Q9JIF4
      UniProtKB/TrEMBL
      Q3UXD9
      Related
      ENSMUSP00000027381.7, ENSMUST00000027381.13
      Conserved Domains (2) summary
      cd05369
      Location:32 → 267
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
      PRK05653
      Location:32 → 267
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      72298331..72323480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MZ7.1 GenPept UniProtKB/Swiss-Prot:Q99MZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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