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    Derl3 Der1-like domain family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 70377, updated on 16-Oct-2021

    Summary

    Official Symbol
    Derl3provided by MGI
    Official Full Name
    Der1-like domain family, member 3provided by MGI
    Primary source
    MGI:MGI:1917627
    See related
    Ensembl:ENSMUSG00000009092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IZP6; derlin-3; 1810006I20Rik; 1810063P04Rik
    Expression
    Biased expression in ovary adult (RPKM 82.9), genital fat pad adult (RPKM 42.8) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Derl3 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75729232..75731775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75893398..75895941)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75356143..75358686)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40697 Neighboring gene macrophage migration inhibitory factor (glycosylation-inhibiting factor) Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene matrix metallopeptidase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118672, MGC144274, MGC144275

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signal recognition particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Hrd1p ubiquitin ligase ERAD-L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    derlin-3
    Names
    degradation in endoplasmic reticulum protein 3
    der1-like protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358983.1NP_001345912.1  derlin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB047555, AK007948, BC099615, BE952795
      Consensus CDS
      CCDS88024.1
      Related
      ENSMUSP00000151623.2, ENSMUST00000217811.2
      Conserved Domains (1) summary
      pfam04511
      Location:13201
      DER1; Der1-like family
    2. NM_001358984.1NP_001345913.1  derlin-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB047555, AC142499, AK007348, AK007948, BC099615, BE952795
      Conserved Domains (1) summary
      pfam04511
      Location:13180
      DER1; Der1-like family
    3. NM_001358985.1NP_001345914.1  derlin-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AB047555, AK007348, BE952795
      Conserved Domains (1) summary
      cl21536
      Location:13161
      Rhomboid; Rhomboid family
    4. NM_024440.2NP_077760.1  derlin-3 isoform 1

      See identical proteins and their annotated locations for NP_077760.1

      Status: VALIDATED

      Source sequence(s)
      AC142499
      Consensus CDS
      CCDS23935.1
      UniProtKB/Swiss-Prot
      Q9D8K3
      UniProtKB/TrEMBL
      Q14C34
      Related
      ENSMUSP00000009236.5, ENSMUST00000009236.6
      Conserved Domains (1) summary
      pfam04511
      Location:13202
      DER1; Der1-like family

    RNA

    1. NR_152573.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB047555, BC099615, BE952795
    2. NR_152574.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB047555, AK007348, BE952795
      Related
      ENSMUST00000218506.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75729232..75731775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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