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    Syt15 synaptotagmin XV [ Mus musculus (house mouse) ]

    Gene ID: 319508, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Syt15provided by MGI
    Official Full Name
    synaptotagmin XVprovided by MGI
    Primary source
    MGI:MGI:2442166
    See related
    Ensembl:ENSMUSG00000041479 AllianceGenome:MGI:2442166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sytXV; CHR10SYT; E230025K04Rik
    Summary
    Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Predicted to be involved in calcium-ion regulated exocytosis; cellular response to calcium ion; and regulation of secretion by cell. Is extrinsic component of membrane. Is expressed in several structures, including brain; heart; lung; skeletal muscle; and testis. Orthologous to human SYT15 (synaptotagmin 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 3.8), ovary adult (RPKM 3.7) and 25 other tissues See more
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    Genomic context

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    Location:
    14 B; 14 20.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33941915..33952378)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34219956..34230421)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex, subunit 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36364 Neighboring gene VISTA enhancer mm340 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene shieldin complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_36366 Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36368 Neighboring gene STARR-seq mESC enhancer starr_36370 Neighboring gene STARR-seq mESC enhancer starr_36372 Neighboring gene STARR-seq mESC enhancer starr_36373 Neighboring gene glutamate dehydrogenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis. Ishihara Y, et al. Toxicol Lett, 2003 Apr 30. PMID 12765241
    2. Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV. Fukuda M. Biochem Biophys Res Commun, 2003 Jun 20. PMID 12788067
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. molecular cloning and structure
      Title: Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176931.2 → NP_795905.2  synaptotagmin-15 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses a different segment for its 3' coding region and UTR, compared to variant a. The resulting protein (isoform b) has a shorter and distinct C-terminus when it is compared to isoform a.
      Source sequence(s)
      AK042641, BC139314
      Consensus CDS
      CCDS49444.1
      UniProtKB/Swiss-Prot
      Q8C6N3
      Related
      ENSMUSP00000113725.2, ENSMUST00000119693.8
      Conserved Domains (2) summary
      cd08390
      Location:146 → 266
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cl14603
      Location:276 → 370
      C2; C2 domain

    2. NM_181529.4 → NP_852682.1  synaptotagmin-15 isoform a

      See identical proteins and their annotated locations for NP_852682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AC154738, BB639494, BC139314
      Consensus CDS
      CCDS26934.1
      UniProtKB/Swiss-Prot
      B2RTF1, Q7TN81, Q7TN82, Q8C6N3, Q8C999
      Related
      ENSMUSP00000036755.6, ENSMUST00000035351.7
      Conserved Domains (2) summary
      cd08390
      Location:146 → 266
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cl14603
      Location:276 → 413
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33941915..33952378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316056.3 → XP_017171545.1  synaptotagmin-15 isoform X1

      Conserved Domains (2) summary
      cd08390
      Location:139 → 259
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cl14603
      Location:269 → 406
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C6N3.1 GenPept UniProtKB/Swiss-Prot:Q8C6N3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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