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    Guk1 guanylate kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14923, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Guk1provided by MGI
    Official Full Name
    guanylate kinase 1provided by MGI
    Primary source
    MGI:MGI:95871
    See related
    Ensembl:ENSMUSG00000020444 AllianceGenome:MGI:95871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gmk; Guk-1
    Summary
    Enables ATP binding activity and guanylate kinase activity. Involved in purine nucleotide metabolic process. Located in cytosol and photoreceptor inner segment. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 72.1), ovary adult (RPKM 53.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 37.05 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59074696..59083068, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59183855..59192207, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene IBA57 homolog, iron-sulfur cluster assembly Neighboring gene STARR-positive B cell enhancer ABC_E5231 Neighboring gene STARR-seq mESC enhancer starr_29616 Neighboring gene gap junction protein, gamma 2 Neighboring gene STARR-positive B cell enhancer ABC_E6990 Neighboring gene RIKEN cDNA 2610507I01 gene Neighboring gene STARR-positive B cell enhancer ABC_E5232 Neighboring gene mitochondrial ribosomal protein L55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural characterization of the closed conformation of mouse guanylate kinase. Sekulic N, et al. J Biol Chem, 2002 Aug 16. PMID 12036965
    2. Cloning, characterization, and modeling of mouse and human guanylate kinases. Brady WA, et al. J Biol Chem, 1996 Jul 12. PMID 8663313
    3. Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3. Wimberg H, et al. Front Mol Neurosci, 2018. PMID 29515371, Free PMC Article
    4. The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Nechiporuk T, et al. Elife, 2016 Jan 8. PMID 26745185, Free PMC Article
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within GDP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in GDP-mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within GMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in GMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dGDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dGMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleoside monophosphate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleotide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate kinase
    Names
    GMP kinase
    NP_001152882.1
    NP_001390762.1
    NP_001390763.1
    NP_001390764.1
    NP_001390765.1
    NP_001390766.1
    NP_032219.2
    XP_006532309.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159410.2 → NP_001152882.1  guanylate kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645854
      Consensus CDS
      CCDS48809.1
      UniProtKB/TrEMBL
      E9Q7K1
      Related
      ENSMUSP00000130214.3, ENSMUST00000170895.4
      Conserved Domains (1) summary
      TIGR03263
      Location:14 → 196
      guanyl_kin; guanylate kinase

    2. NM_001403833.1 → NP_001390762.1  guanylate kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645854
      UniProtKB/TrEMBL
      E9Q7K1
      Conserved Domains (1) summary
      TIGR03263
      Location:14 → 196
      guanyl_kin; guanylate kinase

    3. NM_001403834.1 → NP_001390763.1  guanylate kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645854
      UniProtKB/TrEMBL
      E9Q7K1
      Conserved Domains (1) summary
      TIGR03263
      Location:14 → 196
      guanyl_kin; guanylate kinase

    4. NM_001403835.1 → NP_001390764.1  guanylate kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645854
      UniProtKB/Swiss-Prot
      Q564F2, Q564G0, Q64520

    5. NM_001403836.1 → NP_001390765.1  guanylate kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645854
      UniProtKB/Swiss-Prot
      Q564F2, Q564G0, Q64520

    6. NM_001403837.1 → NP_001390766.1  guanylate kinase isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL645854

    7. NM_008193.4 → NP_032219.2  guanylate kinase isoform 1

      See identical proteins and their annotated locations for NP_032219.2

      Status: VALIDATED

      Source sequence(s)
      AL645854
      Consensus CDS
      CCDS24762.2
      UniProtKB/TrEMBL
      Q564G0
      Related
      ENSMUSP00000127566.3, ENSMUST00000170202.9
      Conserved Domains (2) summary
      TIGR03263
      Location:26 → 208
      guanyl_kin; guanylate kinase
      pfam00625
      Location:24 → 209
      Guanylate_kin; Guanylate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      59074696..59083068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532246.2 → XP_006532309.1  guanylate kinase isoform X1

      See identical proteins and their annotated locations for XP_006532309.1

      UniProtKB/Swiss-Prot
      Q564F2, Q564G0, Q64520
      Related
      ENSMUSP00000134236.3, ENSMUST00000172714.3
      Conserved Domains (1) summary
      TIGR03263
      Location:5 → 187
      guanyl_kin; guanylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64520.2 GenPept UniProtKB/Swiss-Prot:Q64520

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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