Cd209b CD209b antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd209bprovided by MGI
Official Full Name: CD209b antigenprovided by MGI
Primary source: MGI:MGI:1916415
See related: Ensembl:ENSMUSG00000065987 AllianceGenome:MGI:1916415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
Summary: Enables (1->3)-beta-D-glucan binding activity and mannose binding activity. Acts upstream of or within several processes, including detection of other organism; phagocytosis, recognition; and positive regulation of tumor necrosis factor production. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease (multiple); aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 21.2), spleen adult (RPKM 2.2) and 3 other tissues See more
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Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3967655..3976841, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3917655..3926841, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that SIGNR1(CD209b) expressed in Lewis lung cancer cell-educated macrophages appears to mediate IL-4-induced RAW264.7 macrophage polarization and thus facilitate lung cancer evasion.
Title: Lewis Lung Cancer Cells Promote SIGNR1(CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion.
SIGNR1-mediated phagocytosis but not SIGNR1-mediated endocytosis and cell adhesion, suppresses the TLR4-mediated production of specific proinflammatory cytokines via PI3 kinase signaling.
Title: SIGNR1-mediated phagocytosis, but not SIGNR1-mediated endocytosis or cell adhesion, suppresses LPS-induced secretion of IL-6 from murine macrophages.
The subtle carbohydrate preference of SIGNR1 as a phagocytic receptor or as an adhesion molecule is altered depending on the function.
Title: Comparison of the carbohydrate preference of SIGNR1 as a phagocytic receptor with the preference as an adhesion molecule.
mediates uptake of mannose-decorated particles leading to cell maturation of peritoneal DC-like cells
Title: C-type lectin receptor SIGNR1 expressed on peritoneal phagocytic cells with an immature dendritic cell-like phenotype is involved in uptake of oligomannose-coated liposomes and subsequent cell maturation.
SIGNR1 is involved in the inhibition of DC maturation
Title: Secretory IgA induces tolerogenic dendritic cells through SIGNR1 dampening autoimmunity in mice.
SIGN-R1 in the MZ rapidly accelerates C3 deposition on circulating apoptotic cells by interacting with C1q, thus promoting the systemic clearance of apoptotic cells and maintaining immune tolerance in vivo.
Title: SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen.
These results indicate that murine SIGNR1 recognizes C. albicans/yeast through a specificity partly distinct from that of its homologue human DC-SIGN.
Title: Difference in fine specificity to polysaccharides of Candida albicans mannoprotein between mouse SIGNR1 and human DC-SIGN.
enhances TNF-alpha production by macrophages in cooperation with TLR2 upon microbial recognition
Title: Efficient capture of Candida albicans and zymosan by SIGNR1 augments TLR2-dependent TNF-α production.
Toll-like receptor 2-mediated signalling is negatively regulated by SIGNR1-mediated signalling in dendritic cells, possibly through suppressor of cytokine signalling-1-mediated degradation of the MyD88-adaptor-like protein.
Title: Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling.
SIGNR1 was shown to enhance the intracellular oxidative burst of macrophages in response to heat killed C. albicans in cooperation with Dectin-1.
Title: C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables polysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in biological process involved in interspecies interaction between organisms	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of yeast	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD209 antigen-like protein B

Names: DC-SIGN-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037800.3 → NP_001032889.3 CD209 antigen-like protein B isoform b

See identical proteins and their annotated locations for NP_001032889.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AF374471, AF424803, AK138999

Consensus CDS

CCDS22076.1

UniProtKB/Swiss-Prot

Q8CJ91

UniProtKB/TrEMBL

Q3UTX5, Q8CJ85

Related

ENSMUSP00000126070.2, ENSMUST00000171635.8

Conserved Domains (1) summary

cd03590
Location:165 → 287

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_001287211.1 → NP_001274140.1 CD209 antigen-like protein B isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC121948, AF374471, AF424803, AK138999

Consensus CDS

CCDS72089.1

UniProtKB/Swiss-Prot

Q8CJ91

UniProtKB/TrEMBL

Q3UTX5, Q8CJ85

Related

ENSMUSP00000140695.2, ENSMUST00000188386.2

Conserved Domains (1) summary

cd03590
Location:165 → 308

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_026972.5 → NP_081248.4 CD209 antigen-like protein B isoform a

See identical proteins and their annotated locations for NP_081248.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AF373409, AF424803, AK138999

Consensus CDS

CCDS22077.1

UniProtKB/Swiss-Prot

Q8BGZ0, Q8BHK7, Q8CJ86, Q8CJ87, Q8CJ88, Q8CJ89, Q8CJ90, Q8CJ91, Q8CJ92, Q8CJ93, Q8CJ94, Q91ZW4, Q91ZX0, Q9D8V4

UniProtKB/TrEMBL

Q3UTX5

Related

ENSMUSP00000081104.3, ENSMUST00000084086.9

Conserved Domains (1) summary

cd03590
Location:195 → 317

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

RNA

NR_104430.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF424803, AK138999

Related

ENSMUST00000111014.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

3967655..3976841 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508870.4 → XP_006508933.1 CD209 antigen-like protein B isoform X1

Conserved Domains (1) summary

cl02432
Location:203 → 286

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_104431.1: Suppressed sequence

Description

NR_104431.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.