Pde4a phosphodiesterase 4A, cAMP specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde4aprovided by MGI
Official Full Name: phosphodiesterase 4A, cAMP specificprovided by MGI
Primary source: MGI:MGI:99558
See related: Ensembl:ENSMUSG00000032177 AllianceGenome:MGI:99558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dpde2; D9Ertd60e
Summary: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within cellular response to xenobiotic stimulus; regulation of signal transduction; and sensory perception of smell. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 20.4), frontal lobe adult (RPKM 16.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.73 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21076998..21124544)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21165700..21213248)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration.
Title: Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration.
Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.
Title: Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.
In conclusion, our data demonstrated that UFM24 inhibits oxidative burst in human neutrophils through inhibition of PDE4 activity. UFM24 also exhibited significant protection against endotoxin-induced acute lung injury (ALI)in mice. UFM24 has potential as an anti-inflammatory agent for treating neutrophilic lung damage.
Title: 6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury.
PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
Title: PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
results suggest that PDE4A may be important in the regulation of emotional memory and anxiety-like behavior, but not emesis
Title: Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
This study showed that long PDE4 isoforms provide a novel node for cross-talk between the cAMP and p38 MAPK signalling systems at the level of MK2.
Title: Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes.
Title: In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
a new mechanism in which phosphodiesterase PDE4A4/5 interacts with p75(NTR) to enhance cAMP degradation
Title: p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94489 (e-PCR)
- UniSTS:119737

RH126587 (e-PCR)
- UniSTS:167625

Pde4a (e-PCR), detects polymorphism
- UniSTS:507122

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of smell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3',5'-cyclic-AMP phosphodiesterase 4A

Names: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase PDE4A; cyclic AMP specific phosphodiesterase PDE4A5A; dunce

NP_001297679.1

EC 3.1.4.53

NP_001396218.1

EC 3.1.4.53

NP_001396220.1

EC 3.1.4.53

NP_001396221.1

EC 3.1.4.53

NP_001396222.1

EC 3.1.4.53

NP_001396223.1

EC 3.1.4.53

NP_001396224.1

EC 3.1.4.53

NP_001396225.1

EC 3.1.4.53

NP_001396226.1

EC 3.1.4.53

NP_062772.3

EC 3.1.4.53

NP_899668.1

EC 3.1.4.53

XP_030099987.1

EC 3.1.4.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310750.2 → NP_001297679.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 6

See identical proteins and their annotated locations for NP_001297679.1

Status: VALIDATED

Source sequence(s)

AC163637

Consensus CDS

CCDS80964.1

UniProtKB/TrEMBL

Q3TUD0

Related

ENSMUSP00000111118.3, ENSMUST00000115458.9

Conserved Domains (1) summary

pfam00233
Location:361 → 602

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001409289.1 → NP_001396218.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 3

Status: VALIDATED

Source sequence(s)

AC163637
NM_001409291.1 → NP_001396220.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 4

Status: VALIDATED

Source sequence(s)

AC163637
NM_001409292.1 → NP_001396221.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1

Status: VALIDATED

Source sequence(s)

AC163637
NM_001409293.1 → NP_001396222.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 8

Status: VALIDATED

Source sequence(s)

AC163637
NM_001409294.1 → NP_001396223.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 8

Status: VALIDATED

Source sequence(s)

AC163637
NM_001409295.1 → NP_001396224.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 9

Status: VALIDATED

Source sequence(s)

AC163637
NM_001409296.1 → NP_001396225.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 10

Status: VALIDATED

Source sequence(s)

AC163637
NM_001409297.1 → NP_001396226.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 10

Status: VALIDATED

Source sequence(s)

AC163637
NM_019798.6 → NP_062772.3 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1

See identical proteins and their annotated locations for NP_062772.3

Status: VALIDATED

Source sequence(s)

AC163637

Consensus CDS

CCDS22896.1

UniProtKB/TrEMBL

C9K100

Related

ENSMUSP00000003395.10, ENSMUST00000003395.10

Conserved Domains (1) summary

pfam00233
Location:184 → 425

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_183408.4 → NP_899668.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 5

See identical proteins and their annotated locations for NP_899668.1

Status: VALIDATED

Source sequence(s)

AC163637

Consensus CDS

CCDS22895.1

UniProtKB/Swiss-Prot

O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8

UniProtKB/TrEMBL

B2RTL2, Q3TUD0

Related

ENSMUSP00000037025.9, ENSMUST00000039413.15

Conserved Domains (2) summary

pfam00233
Location:418 → 659

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:173 → 288

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

21076998..21124544

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244127.1 → XP_030099987.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

UniProtKB/TrEMBL

C9K100

Conserved Domains (1) summary

pfam00233
Location:100 → 341

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase