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    Slc6a20b solute carrier family 6 (neurotransmitter transporter), member 20B [ Mus musculus (house mouse) ]

    Gene ID: 22599, updated on 3-Apr-2024

    Summary

    Official Symbol
    Slc6a20bprovided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter), member 20Bprovided by MGI
    Primary source
    MGI:MGI:1336891
    See related
    Ensembl:ENSMUSG00000025243 AllianceGenome:MGI:1336891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XT3; Sit1; Xtrp3; Slc6a20
    Summary
    Predicted to enable L-proline transmembrane transporter activity; amino-acid betaine transmembrane transporter activity; and proline:sodium symporter activity. Predicted to be involved in amino-acid betaine transport and cation transport. Located in apical plasma membrane and brush border membrane. Is expressed in blood vessel; choroid plexus; genitourinary system; and meninges. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC6A20 (solute carrier family 6 member 20). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 92.2), duodenum adult (RPKM 16.4) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc6a20b in Genome Data Viewer
    Location:
    9 F4; 9 74.19 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123422888..123461603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123593823..123632538, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E717 Neighboring gene nuclear encoded tRNA arginine 2 (anticodon ACG) Neighboring gene SAC1 suppressor of actin mutations 1-like (yeast) Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 20A Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-proline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proline:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables solute:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in L-proline import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-proline import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proline import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium- and chloride-dependent transporter XTRP3B
    Names
    IMINO-K
    X transporter protein 3
    solute carrier family 6 (neurotransmitter transporter), member 20
    solute carrier family 6, member 20B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410461.1NP_001397390.1  sodium- and chloride-dependent transporter XTRP3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132852, LXEJ02000930
    2. NM_001410462.1NP_001397391.1  sodium- and chloride-dependent transporter XTRP3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132852, LXEJ02000930
    3. NM_011731.4NP_035861.2  sodium- and chloride-dependent transporter XTRP3B isoform 1

      See identical proteins and their annotated locations for NP_035861.2

      Status: VALIDATED

      Source sequence(s)
      AC132852, AK144038
      Consensus CDS
      CCDS23661.1
      UniProtKB/Swiss-Prot
      E9QNK3, O88575, Q3TP52, Q91WT6
      UniProtKB/TrEMBL
      A0A803YV45
      Related
      ENSMUSP00000026273.10, ENSMUST00000026273.11
      Conserved Domains (1) summary
      cl00456
      Location:45620
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      123422888..123461603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)