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    Sftpb surfactant associated protein B [ Mus musculus (house mouse) ]

    Gene ID: 20388, updated on 21-Apr-2024

    Summary

    Official Symbol
    Sftpbprovided by MGI
    Official Full Name
    surfactant associated protein Bprovided by MGI
    Primary source
    MGI:MGI:109516
    See related
    Ensembl:ENSMUSG00000056370 AllianceGenome:MGI:109516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SF-B; SP-B; Sftp3; Sftp-3
    Summary
    Predicted to be involved in sphingolipid metabolic process. Predicted to act upstream of or within respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in respiratory system. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward lung adult (RPKM 2635.4) See more
    Orthologs
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    Genomic context

    Location:
    6 C1; 6 32.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72281594..72291354)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72304610..72314373)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene atonal bHLH transcription factor 8 Neighboring gene predicted gene, 52906 Neighboring gene predicted gene, 30782 Neighboring gene STARR-seq mESC enhancer starr_16282 Neighboring gene ubiquitin specific peptidase 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72295216-72295399 Neighboring gene RIKEN cDNA 0610030E20 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in alveolar lamellar body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pulmonary surfactant-associated protein B
    Names
    pulmonary surfactant-associated proteolipid SPL(Phe)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282071.3NP_001269000.1  pulmonary surfactant-associated protein B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116115, FO681326
      Consensus CDS
      CCDS71775.1
      UniProtKB/TrEMBL
      S4R2L6
      Related
      ENSMUSP00000138695.2, ENSMUST00000183018.8
      Conserved Domains (4) summary
      smart00741
      Location:66142
      SapB; Saposin (B) Domains
      pfam03489
      Location:111142
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:68102
      SapB_1; Saposin-like type B, region 1
      cl02494
      Location:2760
      SapA; Saposin A-type domain
    2. NM_147779.3NP_680088.1  pulmonary surfactant-associated protein B isoform 1 precursor

      See identical proteins and their annotated locations for NP_680088.1

      Status: VALIDATED

      Source sequence(s)
      AC116115, FO681326
      UniProtKB/Swiss-Prot
      P50405
      Related
      ENSMUSP00000138204.4, ENSMUST00000182014.10
      Conserved Domains (4) summary
      smart00741
      Location:66142
      SapB; Saposin (B) Domains
      pfam03489
      Location:111142
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:68102
      SapB_1; Saposin-like type B, region 1
      cl02494
      Location:2760
      SapA; Saposin A-type domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72281594..72291354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)