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    H2ac15 H2A clustered histone 15 [ Mus musculus (house mouse) ]

    Gene ID: 319169, updated on 6-May-2021

    Summary

    Official Symbol
    H2ac15provided by MGI
    Official Full Name
    H2A clustered histone 15provided by MGI
    Primary source
    MGI:MGI:2448297
    See related
    Ensembl:ENSMUSG00000063021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hist1h; Hist1h2ak
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
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    Genomic context

    See H2ac15 in Genome Data Viewer
    Location:
    13; 13 A3.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21937547..21938082, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21753377..21753912, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (21845304..21845696, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 11 Neighboring gene H4 clustered histone 12 Neighboring gene H2B clustered histone 15 Neighboring gene predicted gene 11274

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histone H2A type 1-K
    Names
    histone 1, H2ak
    histone cluster 1, H2ak

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178183.2NP_835490.1  histone H2A type 1-K

      See identical proteins and their annotated locations for NP_835490.1

      Status: REVIEWED

      Source sequence(s)
      AL589651
      Consensus CDS
      CCDS26293.1
      UniProtKB/Swiss-Prot
      Q8CGP7
      Related
      ENSMUSP00000074310.3, ENSMUST00000074752.4
      Conserved Domains (2) summary
      PTZ00017
      Location:1130
      PTZ00017; histone H2A; Provisional
      cd00074
      Location:6120
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21937547..21938082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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