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    Mogat1 monoacylglycerol O-acyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68393, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mogat1provided by MGI
    Official Full Name
    monoacylglycerol O-acyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1915643
    See related
    Ensembl:ENSMUSG00000012187 AllianceGenome:MGI:1915643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mDC2; MGAT1; Dgat2l; Dgat2l1; 0610030A14Rik; 1110064N14Rik; WI1-2612I11.1
    Summary
    Enables 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Acts upstream of or within diacylglycerol biosynthetic process. Located in endoplasmic reticulum and membrane. Orthologous to human MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 21.9), kidney adult (RPKM 14.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C4; 1 40.59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78487697..78597882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78511060..78606964)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene STARR-positive B cell enhancer ABC_E4327 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene phenylalanyl-tRNA synthetase, beta subunit Neighboring gene STARR-positive B cell enhancer ABC_E9179 Neighboring gene STARR-seq mESC enhancer starr_01427 Neighboring gene STARR-positive B cell enhancer ABC_E5774 Neighboring gene STARR-positive B cell enhancer ABC_E322 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683 Neighboring gene STARR-seq mESC enhancer starr_01433 Neighboring gene STARR-positive B cell enhancer ABC_E5775 Neighboring gene UTP14B small subunit processome component Neighboring gene acyl-CoA synthetase long-chain family member 3 Neighboring gene predicted gene, 51635

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice. Singer JM, et al. Obesity (Silver Spring), 2022 Nov. PMID 36321276, Free PMC Article
    2. Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1. Lutkewitte AJ, et al. Mol Metab, 2021 Jul. PMID 33676028, Free PMC Article
    3. Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis. Yu JH, et al. Sci Rep, 2016 Jul 11. PMID 27404390, Free PMC Article
    4. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. Agarwal AK, et al. J Lipid Res, 2016 Apr. PMID 26880786, Free PMC Article
    5. Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice. Hall AM, et al. Diabetes, 2014 Jul. PMID 24595352, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exercise intensity impacts the improvement of metabolic dysfunction-associated steatotic liver disease via variations of monoacylglycerol O-acyltransferase 1 expression.
      Title: Exercise intensity impacts the improvement of metabolic dysfunction-associated steatotic liver disease via variations of monoacylglycerol O-acyltransferase 1 expression.
    2. Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice.
      Title: Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice.
    3. Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1.
      Title: Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1.
    4. demonstrate that chronic ethanol ingestion activates peroxisome proliferator-activated receptor gamma (PPARgamma) and its target gene, monoacylglycerol O-acyltransferase 1 (MGAT1)
      Title: Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis.
    5. a minimal role, if any, of MOGAT1 in liver TAG synthesis
      Title: Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.
    6. Inactivation of hepatic MGAT activity, which is markedly increased in obese mice, improved glucose tolerance and hepatic insulin signaling independent of changes in body weight, intrahepatic DAG and TAG content, and PKC signaling.
      Title: Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.
    7. MGAT1 identified, biochemical characteristics and tissue distribution reported.
      Title: Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • MGC118035

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-acylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within diacylglycerol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-acylglycerol O-acyltransferase 1
    Names
    acyl-CoA:monoacylglycerol acyltransferase 1
    diacylglycerol O-acyltransferase 2-like 1
    diacylglycerol acyltransferase 2-like protein 1
    NP_080989.2
    XP_011237009.1
    XP_017177770.1
    XP_017177774.1
    XP_036009175.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026713.3 → NP_080989.2  2-acylglycerol O-acyltransferase 1

      See identical proteins and their annotated locations for NP_080989.2

      Status: VALIDATED

      Source sequence(s)
      AK002693, BE626067, CB601805
      Consensus CDS
      CCDS15085.1
      UniProtKB/Swiss-Prot
      E9QLA2, Q91ZV4, Q9DCL0
      Conserved Domains (1) summary
      cl17185
      Location:41 → 335
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      78487697..78597882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238707.4 → XP_011237009.1  2-acylglycerol O-acyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      D3YW64
      Conserved Domains (1) summary
      cl17185
      Location:3 → 297
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    2. XM_017322281.3 → XP_017177770.1  2-acylglycerol O-acyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      E9QLA2, Q91ZV4, Q9DCL0
      Related
      ENSMUSP00000109152.2, ENSMUST00000113524.8
      Conserved Domains (1) summary
      cl17185
      Location:41 → 335
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    3. XM_036153282.1 → XP_036009175.1  2-acylglycerol O-acyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      E9QLA2, Q91ZV4, Q9DCL0
      Related
      ENSMUSP00000012331.7, ENSMUST00000012331.7
      Conserved Domains (1) summary
      cl17185
      Location:41 → 335
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    4. XM_017322285.2 → XP_017177774.1  2-acylglycerol O-acyltransferase 1 isoform X3

      Conserved Domains (1) summary
      cl17185
      Location:29 → 207
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RNA

    1. XR_004934156.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZV4.2 GenPept UniProtKB/Swiss-Prot:Q91ZV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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